CYP11A1基因多态性与老年性骨质疏松性骨折相关性研究

发布时间：2018-06-17 09:53

  本文选题：CYPA基因 + 多态性　； 参考：《中国骨质疏松杂志》2017年03期

【摘要】：目的探讨CYP11A1基因rs900798位点多态性与老年性骨质疏松性骨折骨转换标志物的关系。方法研究对象为121例老年性骨质疏松性骨折患者(骨折组),114例老年性骨质疏松症患者(对照组)。骨折组中胸椎骨折、腰椎骨折、胸腰椎骨折、股骨颈骨折、粗隆间骨折、肱骨近端骨折和桡骨远端例数分别为32例、40例、3例、19例、20例、4例和3例。采用SNa Pshot法进行SNP分型,化学发光法测定血清Ⅰ型前胶原氨基端前肽(PINP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)浓度。计算两组等位基因频率、基因型频率并分析骨折组CYP11A1基因多态性与PINP、β-CTX的关系。结果两组rs900798位点等位基因基因频率和基因型频率分布符合哈迪温伯格平衡。骨折组和对照组G、T等位基因频率分别为40.1%、59.9%和38.2%、61.8%,差异无统计学意义(P0.05);两组GG、GT、TT基因型频率分别为14.9%、50.4%、34.7%和13.2%、50.0%、36.8%,差异无统计学意义(P0.05)。骨折组和对照组血清PINP、β-CTX差异无统计学意义(P0.05)。骨折组中GG、GT、TT基因型的PINP、β-CTX差异无统计学意义(P0.05)。结论 CYP11A1基因rs900798位点多态性与老年性骨质疏松性骨折患者血清PINP、β-CTX无相关性。
[Abstract]:Objective to investigate the relationship between rs900798 polymorphism of CYP11A1 gene and bone turnover markers in senile osteoporosis fracture. Methods 121 cases of senile osteoporotic fracture (fracture group, 114 cases of senile osteoporosis, control group) were studied. In the fracture group, the cases of thoracic vertebral fracture, lumbar vertebra fracture, thoracolumbar vertebrae fracture, femoral neck fracture, intertrochanteric fracture, proximal humerus fracture and distal radius fracture were 32 cases, 40 cases, 3 cases, and 19 cases, 20 cases and 3 cases, respectively. SNP typing was carried out by SNa shot method. The concentration of serum procollagen type I amino terminal prepeptide (PINPX) and type 鈪，

本文编号：2030619