某蓄电池厂工人血铅水平及其与血锌原卟啉的相关性

发布时间：2018-06-18 01:39

本文选题：血铅值 + 锌原卟啉　；参考：《环境与职业医学》2017年04期

【摘要】：[目的]探讨影响职业性铅作业工人血铅水平的因素,并分析其与血锌原卟啉(ZPP)的相关性。[方法]以江苏省某蓄电池厂所有454名员工(男性300名,女性154名)作为研究对象,对其工作岗位空气中铅浓度进行现场检测。采用问卷调查的形式记录工人吸烟、饮酒等行为习惯,测定其血铅及ZPP,将血铅质量浓度大于400μg/L作为高血铅组,100μg/L作为低血铅组,100~400μg/L之间的人群作为中血铅组,进行统计分析。以血铅作为接触标志,ZPP作为效应标志,采用基准剂量计算软件(BMDS 2.6.1)计算血铅基准剂量和基准剂量的95%可信区间下限(BMDL)。[结果]三组研究对象的单因素分析中,血铅值、年龄、受教育程度、工种、工龄、接铅工龄、吸烟和饮酒分布差异有统计学意义;logistic回归分析发现受教育程度低、工种为操作工、饮酒、接铅工龄短是血铅水平增高的危险因素;线性相关分析显示血铅在100~400μg/L范围内和ZPP具有正相关性(P0.001)。以血铅作为接触标志,ZPP作为效应标志,血铅基准剂量和BMDL分别为562.23μg/L和441.13μg/L(P=0.78)。[结论]在血铅水平较高时,血铅与ZPP具有较好的正相关性,ZPP是铅接触的敏感效应生物标志。在实际工作中应用ZPP作为低血铅水平(100μg/L)的筛查指标时,应注意和其他指标联合应用。
[Abstract]:[objective] to investigate the factors influencing blood lead level in workers exposed to occupational lead, and to analyze its correlation with ZPPs in blood zinc protoporphyrin. [methods] A total of 454 employees (300 males and 154 females) from a battery factory in Jiangsu Province were studied. The smoking and drinking behaviors of workers were recorded by questionnaire, and their blood lead and ZPPs were measured. The blood lead concentration was more than 400 渭 g / L in the high blood lead group and 100 渭 g / L in the low blood lead group as the middle blood lead group, and the blood lead concentration was 100 渭 g / L in the low blood lead group and 400 渭 g / L in the low blood lead group. Blood lead was used as the contact marker and ZPP was used as the effect marker. The reference dose calculation software (BMDS 2.6.1) was used to calculate the blood lead baseline dose and the lower limit of 95% confidence interval of the reference dose. [results] in univariate analysis of the three groups, there were significant differences in the distribution of blood lead, age, education, type of work, length of service, exposure to lead, smoking and alcohol consumption. Logistic regression analysis showed that the educational level was low. The risk factors for the increase of blood lead level were drinking alcohol and short lead exposure, and the linear correlation analysis showed that there was a positive correlation between blood lead and ZPP in the range of 100 渭 g / L and ZPP (P 0.001 / L). Using blood lead as the contact marker, the baseline dose of blood lead and BMDL were 562.23 渭 g / L and 441.13 渭 g / L respectively. [conclusion] when the level of blood lead is high, blood lead and ZPP have a good positive correlation. ZPP is a sensitive biomarker of lead exposure. When using ZPP as a screening index of 100 渭 g / L low blood lead level in practical work, we should pay attention to the application of ZPP in combination with other indexes.
【作者单位】：东南大学公共卫生学院;江苏省疾病预防控制中心职业病防治所;
【基金】：江苏省临床医学科技专项(编号:BL2014082)
【分类号】：R135.11

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