HLA-B27阳性与阴性中轴型脊柱关节炎临床特征分析

发布时间：2018-06-19 21:55

本文选题：中轴型脊柱关节炎 + HLA-B抗原　；参考：《实用医学杂志》2017年12期

【摘要】：目的:探讨HLA-B27在中轴型脊柱关节炎疾病活动与临床特征中的作用。方法:前瞻性收集并观察研究112例中轴型SpA患者的病例资料,分析82例HLA-B27阳性和30例HLA-B27阴性中轴型SpA患者的临床表现及实验室检查结果。数据来源为国家风湿病数据中心。结果:(1)HLA-B27阴性患者较阳性患者平均发病年龄明显偏晚,男女比例、病程无显著差异。(2)HLA-B27阴性组的严重髋关节病变、外周关节炎、附着点炎及全身症状的比率均明显低于HLA-B27阳性组,家族聚集现象、葡萄膜炎和脊柱的放射学改变在两组差异无显著性。(3)疾病活动性指标的改变包括血沉和C-反应蛋白的升高HLA-B27阴性组明显低于HLA-B27阳性组。结论:中轴型SpA与HLA-B27相关性强,HLA-B27阳性患者平均发病年龄明显偏早,病情相对较重,预后较差。HLA-B27
[Abstract]:Objective: to investigate the role of HLA-B27 in the activity and clinical features of axial spinal arthritis. Methods: 112 cases of central axis spa were collected and studied prospectively. The clinical manifestations and laboratory findings of 82 patients with HLA-B27 positive and 30 patients with negative HLA-B27 were analyzed. The source of the data is the National data Center for Rheumatology. Results the average onset age of HLA-B27 negative patients was significantly later than that of positive patients, and the ratio of male to female had no significant difference. The rates of severe hip disease, peripheral arthritis, attachment point inflammation and systemic symptoms in HLA-B27 negative group were significantly lower than those in HLA-B27 positive group. Family aggregation, radiologic changes of uveitis and spine were not significantly different between the two groups. The changes of disease activity including ESR and C-reactive protein were significantly lower in HLA-B27 negative group than in HLA-B27 positive group. Conclusion: the average onset age of patients with strong correlation between central axis spa and HLA-B27 positive patients is significantly earlier, the disease is relatively serious, and the prognosis of HLA-B27 is poor.
【作者单位】：南昌大学第二附属医院风湿免疫科;
【分类号】：R593.2

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