不同糖耐量人群血浆血管内皮生长因子-B水平与胰岛素抵抗的相关性研究

发布时间：2018-06-19 22:39

本文选题：血管内皮生长因子B + 胰岛素抵抗　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:检测不同糖耐量人群血浆血管内皮生长因子B(VEGF-B)水平变化,探讨其与糖脂代谢、肥胖及胰岛素抵抗(IR)的关系。方法:纳入新诊断2型糖尿病患者(T2DM组)、糖耐量异常者(IGT组)、糖耐量正常者(NGT)组共261例。行葡萄糖耐量试验,并同时检测血糖、胰岛素、糖化血红蛋白(Hb A1C)、血脂等指标,计算HOMA-β、HOMA-IR评估胰岛功能及胰岛素抵抗;再以BMI=25kg/m2为切点将其分为非肥胖组(包括正常体重者和超重者)和肥胖组。ELISA测定不同糖耐量者血浆VEGF-B水平,分析血浆VEGF-B水平与相关代谢指标及胰岛素抵抗的关系。结果:T2DM组、IGT组血浆VEGF-B水平高于NGT组[(194.87±61.80)vs(148.46±45.68)vs(111.64±32.49)pg/ml,P0.01]。总人群中肥胖组血浆VEGF-B水平高于非肥胖组[(169.39±60.58)vs(118.91±48.88)pg/ml,P0.01]。相关性分析显示,血浆VEGF-B水平与BMI、WHR、TG、FFA、FPG、FIns、HOMA-IR呈正相关(P0.01),进一步矫正BMI、WHR后,血浆VEGF-B水平与HOMA-IR仍呈正相关。多元线性逐步回归分析表明,T2DM组HOMA-IR、BMI是血浆VEGF-B水平的独立影响因素(R2=0.405、0.432,P0.05)。结论:血浆VEGF-B水平在新诊断T2DM、IGT及肥胖人群中升高,且其与糖脂代谢、IR有关,可能参与2型糖尿病的发生与发展。
[Abstract]:Aim: to detect the changes of plasma vascular endothelial growth factor (VEGF-B) levels in different glucose tolerance subjects and to explore the relationship between VEGF-B and glucose and lipid metabolism, obesity and insulin resistance (IRR). Methods: a total of 261 patients with newly diagnosed type 2 diabetes mellitus (T2DM), IGT with impaired glucose tolerance (IGT) and NGT with normal glucose tolerance (NGT) were enrolled. Glucose tolerance test was performed, blood glucose, insulin, glycosylated hemoglobin HbA1CX, blood lipids were measured at the same time. HOMA- 尾 -HOMA-IR was used to evaluate islet function and insulin resistance. The plasma VEGF-B levels were determined by Elisa in non-obese group (including normal weight group and overweight group) and obese group. The relationship between plasma VEGF-B level and related metabolic indexes and insulin resistance was analyzed. Results the level of VEGF-B in the IGT group was higher than that in the NGT group [194.87 卤45.68)vs(111.64 卤32.49 PG / ml P0.01]. The plasma VEGF-B level in obese group was higher than that in non-obese group (169.39 卤48.88 60.58)vs(118.91 卤48.88 PG / ml P0.01). Correlation analysis showed that plasma VEGF-B level was positively correlated with HOMA-IR of BMI-WHRG / FFAFP FInsInsn, and the plasma VEGF-B level was still positively correlated with HOMA-IR after further correction of BMI-WHR. Multiple linear stepwise regression analysis showed that HOMA-IRN BMI was an independent factor influencing plasma VEGF-B level in T2DM group. Conclusion: the plasma VEGF-B level is increased in newly diagnosed T2DMN IGT and obese population, and it may be involved in the occurrence and development of type 2 diabetes mellitus.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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