血清胆红素水平与绝经后骨质疏松症相关性的临床分析

发布时间：2018-06-22 12:45

本文选题：血清总胆红素 + 绝经后骨质疏松症　；参考：《中国骨质疏松杂志》2017年07期

【摘要】：目的探讨血清总胆红素在绝经后骨质疏松症发病机制中的作用。方法通过双能X线骨密度仪检查,将282例绝经后女性分为正常骨量组(n=93)和早期绝经后骨质疏松症组(n=61)、中期绝经后骨质疏松症组(n=58)和晚期绝经后骨质疏松症组(n=70)。测定血清总胆红素和骨转换标志物水平,分析血清总胆红素与骨密度、骨代谢的关系。结果骨密度与年龄、I型胶原交联C-末端顶端肽(β-CTX)、甲状旁腺激素(parathyroid hormone,PTH)呈负相关,与体重指数(body mass index,BMI)、25羟基维生素D3(25(OH_2)D_3)、血清总胆红素(total bilirubin,TBIL)呈正相关。Logistics回归分析显示,年龄、BMI、TBIL、PTH、总I型前胶原N-末端肽与骨质疏松症的发生独立相关,而血清碱性磷酸酶(alkaline phosphatase,ALP)、β-CTX与绝经后骨质疏松无独立相关性。结论血清总胆红素水平下降为绝经后骨质疏松症的独立危险因素。
[Abstract]:Objective to investigate the role of serum total bilirubin in the pathogenesis of postmenopausal osteoporosis. Methods 282 postmenopausal women were divided into normal bone mass group (n = 93), early postmenopausal osteoporosis group (n = 61), postmenopausal osteoporosis group (n = 58) and postmenopausal osteoporosis group (n = 70) by dual energy X-ray absorptiometry. Serum total bilirubin and bone turnover markers were measured, and the relationship between serum total bilirubin and bone mineral density and bone metabolism was analyzed. Results BMD was negatively correlated with age type I collagen cross-linked C-terminal peptide (尾 -CTX), parathyroid hormone (parathyroid), and positively correlated with body mass index (body mass), 25-hydroxyvitamin D3 (25 (OH2) D3), serum total bilirubin tibil (total bilirubin tibil). There was no independent correlation between serum alkaline phosphatase and 尾 -CTX and postmenopausal osteoporosis. Conclusion the decrease of serum total bilirubin level is an independent risk factor for postmenopausal osteoporosis.
【作者单位】：厦门大学附属中山医院老年医学部;
【分类号】：R580

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