HIF-1α调节糖尿病血管平滑肌成骨样变的研究进展

发布时间：2018-06-22 22:54

本文选题：糖尿病 + 血管钙化　；参考：《生理科学进展》2017年05期

【摘要】：糖尿病血管钙化是糖尿病严重的并发症,这类患者病情相对复杂、各类并发症多、治疗难度大,呈现高发病率、高致残率、高死亡率的形势。新近的观点认为血管钙化形成过程是中膜的血管平滑肌细胞(vascular smooth muscle cells,VSMCs)向成骨样细胞表型转变的一个骨发育类似的主动、可预防、可逆转的可调控过程。既往研究着重于探讨低氧诱导因子-1α(hypoxia inducible fator1,HIF-1α)与糖尿病血管新生的关系,而对于其与血管VSMCs成骨样变的关联未见综述报道。基于此,本文将结合相关文献,从HIF-1α结构及其功能、表达调控机制、阻断剂应用、HIF-1α与糖尿病VSMCs成骨样变的关系四个方面做一综述。
[Abstract]:Vascular calcification of diabetes mellitus is a serious complication of diabetes mellitus. This kind of patients' condition is relatively complex, many kinds of complications, the treatment is difficult, presents the situation of high incidence, high disability rate and high mortality. Recently, it is believed that the process of vascular calcification is a similar active, preventable and reversible process of bone development during the phenotypic transition of vascular smooth muscle cells (vascular smooth muscle cells) to osteoblast-like cells. Previous studies have focused on the relationship between hypoxia inducible factor-1 伪 (hypoxia inducible fator1HIF-1 伪) and diabetic angiogenesis. Based on this, this article will review the relationship between the structure and function of HIF-1 伪, the mechanism of expression regulation, and the relationship between HIF-1 伪 and osteogenesis of diabetic VSMCs.
【作者单位】：中山大学孙逸仙纪念医院心脏外科;中山大学附属第五医院消化内科;
【基金】：广东省自然科学基金(2016A030313295) 中山大学大型新兴交叉学科资助项目(15ykjc17b)资助课题
【分类号】：R587.2

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