胰岛β细胞系研究概况

发布时间：2018-06-23 05:33

本文选题：细胞系 + 胰岛　；参考：《动物医学进展》2017年03期

【摘要】：胰岛具有控制能量代谢的重要作用。全球糖尿病发病率快速增加,引起了科学家对胰岛细胞生物学研究的重视。然而,胰岛分离困难,且费用昂贵,胰岛功能在生物及分子水平上很难获得更加全面的认识。过去胰岛来源的细胞系由于其分化不稳定,仅作为原代胰岛细胞的替代品。如今,人们通过紫外线照射、病毒转染等方法建立了多种胰岛β细胞系,保持了很多正常胰岛的关键功能特性,而成为研究胰岛细胞生物学的有效工具。不同种类细胞系的生物学特征各有不同,根据研究需要,采用基因工程的方法创建更适合的亚系,是迄今为止改善细胞系特性的主要方法,为不同方面的研究提供便利。
[Abstract]:Islets play an important role in controlling energy metabolism. The rapid increase in the incidence of diabetes worldwide has attracted scientists' attention to the study of islet cell biology. However, islet separation is difficult and expensive, and it is difficult to obtain a more comprehensive understanding of islet function at biological and molecular level. In the past, islet derived cell lines were used as substitutes for primary islet cells due to their unstable differentiation. Nowadays, many kinds of islet 尾 cell lines have been established by ultraviolet radiation and virus transfection, which maintain the key functional characteristics of normal islets and become an effective tool for studying the biology of islet cells. The biological characteristics of different cell lines are different. According to the need of research, genetic engineering is the main method to improve the characteristics of cell lines.
【作者单位】：沈阳农业大学畜牧兽医学院;
【基金】：国家自然科学基金项目(31402160)
【分类号】：R587.1

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