类风湿关节炎患者血浆PZ和ZPI的表达及意义

发布时间：2018-06-23 21:38

本文选题：易栓症 + 类风湿关节炎　；参考：《青海大学》2016年硕士论文

【摘要】：目的:通过测定RA患者血浆PZ、ZPI水平,研究探讨PZ和ZPI在易栓性疾病RA患者血浆中水平的变化和意义。方法:采用双抗体夹心酶联免疫吸附法测定42例RA患者及33例健康对照者血浆PZ和ZPI的水平。结果:(1)RA组血浆ZPI水平明显高于对照组血浆ZPI水平,差异有统计学意义(P0.01),RA组血浆PZ水平与对照组血浆PZ水平差异无统计学意义(P0.05);(2)RA组血浆FIB水平明显高于对照组血浆FIB水平,差异有统计学意义(P0.01),RA组FDP水平明显高于对照组FDP水平,差异有统计学意义(P0.01)。(3)RA组血浆ZPI水平与RA组血浆FIB水平呈正相关(P㩳0.01)。(4)RA组血浆PZ水平、ZPI水平与DAS28水平均没有相关性(P0.05)。结论:(1)ZPI可能参与了易栓性疾病RA的抗凝血过程,在RA患者体内代偿性增高。(2)RA患者血浆PZ水平可能无显著性变化。(3)RA患者血浆PZ、ZPI水平可能与DAS28水平均没有相关性。
[Abstract]:Objective: to investigate the changes and significance of PZ and ZPI in patients with thrombotic disease by measuring the plasma PZ ZPI levels in RA patients. Methods: the plasma levels of PZ and ZPI were measured by double antibody sandwich enzyme linked immunosorbent assay (Elisa) in 42 RA patients and 33 healthy controls. Results: (1) the level of plasma ZPI in RA group was significantly higher than that in control group (P0.01). There was no significant difference in plasma PZ level between RA group and control group (P0.05). The plasma level of); (in RA group was significantly higher than that in control group. The difference was statistically significant (P0.01). The level of). (in RA group was significantly higher than that in control group (P0.01). (3). There was a positive correlation between the level of plasma). (in RA group and that in RA group (P0.01). (4). There was no correlation between the level of plasma PZ level and the level of DAS28 in RA group (P0.05). Conclusion: (1) ZPI may be involved in the anticoagulant process of RA and may increase compensatory activity in RA patients. (2) there may be no significant change in plasma PZ level in RA patients. (3) there may be no correlation between plasma PZ and DAS28 levels in RA patients.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R593.22

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