糖化血红蛋白达标与否对2型糖尿病患者认知功能的影响研究

发布时间：2018-06-25 09:26

本文选题：糖尿病 + 型　；参考：《中国全科医学》2016年02期

【摘要】：目的探讨糖化血红蛋白(HbA_(1c))是否达标对2型糖尿病(T2DM)患者认知损伤的影响。方法选择2013年4月—2014年9月唐山工人医院内分泌科住院的T2DM患者255例,男119例、女136例。分为HbA_(1c)7.0%组(A组)、HbA_(1c)7.0%~9.0%组(B组)和HbA_(1c)9.0%组(C组),采用可重复的成套神经心理状态测验(RBANS)量表评估患者的认知功能,比较组间RBANS评分,分析T2DM患者认知评分的影响因素。结果 T2DM患者RBANS总分与年龄(r=-0.20)、受教育程度(r=0.35)、病程(r=-0.13)及HbA_(1c)(r=-0.19)相关(P0.05);多元回归分析显示,受教育程度(t=6.16)、HbA_(1c)(t=-4.61)是T2DM患者RBANS总分的影响因素(P0.05)。校正性别、年龄、受教育程度等因素后,3组患者的即刻记忆(F=14.1)、延迟记忆(F=17.2)和RBANS总分(F=15.9)比较,差异均有统计学意义(P0.05),B、C组RBANS总分均低于A组,差异有统计学意义(P0.05)。结论 HbA_(1c)未达标的T2DM患者认知功能损伤较严重,控制HbA_(1c)在达标范围内对预防T2DM患者认知损伤有潜在价值。
[Abstract]:Objective to investigate the effect of glycosylated hemoglobin (HbA1c) on cognitive impairment in patients with type 2 diabetes mellitus (T2DM). Methods 255 T2DM patients, 119 males and 136 females, were selected from the Endocrinology Department of Tangshan Workers Hospital from April 2013 to September 2014. Patients were divided into HbA1c 7.0% group (A group) and HbA1c 7.0% group (B group) and HbA1c 9.0% group (C group). The cognitive function of patients was evaluated by repeated neuropsychological status test (RBANS). The scores of RBANS were compared between groups, and the influencing factors of cognitive scores of T2DM patients were analyzed. Results the total score of RBANS in T2DM patients was correlated with age (r = -0.20), education level (r = 0.35), course of disease (r = 0.13) and HbA1c (r = 0.19) (P0.05), and multiple regression analysis showed that education level (tr = 6.16), HbA1c (tbA1c) (t = 4.61) was a factor influencing the total score of RBANs in T2DM patients (P0.05). After adjusting for gender, age, education and other factors, the total scores of immediate memory (FN14.1), delayed memory (FF17.2) and RBANS (F15.9) were significantly lower in group C than in group A (P0.05). Conclusion the cognitive impairment of T2DM patients with HbA1c substandard is more serious, and the control of HbA1c has potential value in preventing cognitive impairment in T2DM patients.
【作者单位】：唐山工人医院内分泌二科;唐山工人医院神经外科;唐山工人医院烧伤科;
【基金】：河北省自然科学基金资助项目(H2015105083)
【分类号】：R587.2

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