TCF7L2基因多态性与新疆维吾尔族人群2型糖尿病的相关性研究

发布时间：2018-06-27 08:44

本文选题：TCFL基因 + 糖尿病　；参考：《中国全科医学》2015年02期

【摘要】：目的研究新疆地区维吾尔族人群TCF7L2基因单核苷酸多态性与2型糖尿病的相关性。方法 2012年3月—2013年3月,应用基质辅助激光解吸附电离飞行时间质谱分析质谱技术(MALDI-TOF),对新疆医科大学第一附属医院就诊的维吾尔族2型糖尿病患者969例(T2DM组)和958例体检健康者(NC组)的rs12255372和rs7085532进行基因分型;同时进行人体测量学及代谢指标的检测。结果两组rs12255372多态性位点3种基因型,T、G等位基因频率比较,差异均有统计学意义(P0.05)。非条件Logistic回归分析显示,T等位基因携带者患2型糖尿病的风险为G等位基因携带者的1.238倍〔OR=1.238,95%CI(1.049,1.461),P0.05〕;校正年龄、性别后GT基因型携带者患2型糖尿病的风险为GG基因型携带者的1.221倍〔OR=1.221,95%CI(1.001,1.490),P0.05〕;GT+TT基因型携带者患2型糖尿病的风险为GG基因型携带者的1.252倍〔OR=1.252,95%CI(1.033,1.516),P0.05〕。两组rs7085532多态性位点3种基因型,A、G等位基因频率比较,差异均无统计学意义(P0.05)。结论 TCF7L2基因rs12255372多态性位点可能与新疆维吾尔族人群2型糖尿病相关,而rs7085532多态性位点可能与新疆维吾尔族人群2型糖尿病无相关性。
[Abstract]:Objective to study the association between TCF7L2 gene single nucleotide polymorphism and type 2 diabetes mellitus in Uygur population in Xinjiang. Methods March 2012-March 2013, Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF) was used to analyze 969 Uygur patients with type 2 diabetes mellitus (T2DM group) and 958 healthy controls (NC group) in the first affiliated Hospital of Xinjiang Medical University. Rs12255372 and rs7085532 were genotyped. At the same time, the anthropometric and metabolic indexes were detected. Results there were significant differences in allele frequencies of three genotypes of rs12255372 polymorphism between the two groups (P0.05). Non-conditional logistic regression analysis showed that the risk of type 2 diabetes in T allele carriers was 1.238 times higher than that in G alleles (OR 1.23895 CI (1.049 卤1.461) P 0.05). The risk of type 2 diabetes in GG genotype carriers was 1.252 times higher than that in GG genotype carriers (ORG 1.221T 95 CI (1.001 卤1.490) P 0.05). The risk of type 2 diabetes in GT TT carriers was 1.252 times higher than that in GG genotype carriers (ORG 1.252% 95 CI (1.0331.516) P 0.05). There was no significant difference in allele frequencies of three genotypes of rs7085532 polymorphism between the two groups (P0.05). Conclusion the rs12255372 polymorphism of TCF7L2 gene may be associated with type 2 diabetes in Xinjiang Uygur population, while the rs7085532 polymorphism locus may not be associated with type 2 diabetes in Xinjiang Uygur population.
【作者单位】：新疆医科大学公共卫生学院;新疆医科大学第一附属医院代谢性疾病重点实验室;新疆医科大学第一附属医院体检与健康管理中心;
【基金】：国家重点基础研究发展计划(973计划)(2012CB722403) 新疆重大疾病医学重点实验室开放课题(SKLIB-XJMDR-2012-Y4)
【分类号】：R587.1

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