2型糖尿病患者血清Trx、Txnip与认知功能的相关性

发布时间：2018-06-28 19:41

本文选题：型糖尿病 + 认知功能　；参考：《中国现代医学杂志》2017年03期

【摘要】：目的探讨2型糖尿病(T2DM)患者血清硫氧还蛋白(Trx)、硫氧还蛋白互作蛋白(Txnip)水平及Trx活性与认知功能的相关性,为T2DM患者认知功能障碍的防治提供新思路。方法选取2014~2015年在河北省唐山市工人医院内分泌科住院的T2DM患者100例作为病例组,同时选取正常健康人群90例作为对照组。收集以上所有研究对象的人口学资料(年龄、性别、教育程度、体重指数、病程等)及临床生化指标[空腹血糖(FPG)、糖化血红蛋白(HbA1C)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)],并进行认知功能量表(RBANS)(包括即时记忆、视觉广度、言语功能、注意力、延迟记忆)评分。血清Trx、Txnip水平采用酶联免疫吸附法检测,Trx活性采用胰岛素还原法检测。结果 1与正常对照组比较,T2DM患者FPG、HbA1C、TG、Trx、Txnip水平升高(P0.05),Trx活性降低(P0.05);2与正常对照组比较,T2DM患者RBANS量表即时记忆、延迟记忆、总分降低(P0.05);3在T2DM患者患者中血清Trx、Txnip水平与空腹血糖、糖化血红蛋白呈正相关(P0.05),Trx活性与Txnip水平呈负相关(P0.05);4血清Trx、Txnip水平与RBANS量表延迟记忆、总分呈负相关(P0.05);Trx活性与其呈正相关(P0.05)。结论血清Trx、Txnip升高,以及Trx活性降低可能是T2DM患者出现认知功能障碍的一个危险因素。
[Abstract]:Objective to investigate the correlation between serum thioredoxin (Trx), thioredoxin interaction protein (Txnip) and cognitive function in patients with type 2 diabetes mellitus (T2DM), and to provide a new approach for the prevention and treatment of cognitive dysfunction in patients with type 2 diabetes mellitus (T2DM). Methods 100 cases of T2DM patients hospitalized in Endocrinology Department of Workers Hospital of Tangshan City Hebei Province from 2014 to 2015 were selected as case group and 90 healthy people as control group. Collect demographic data (age, sex, education, body mass index) for all of the above subjects. Clinical biochemical parameters [fasting blood glucose (FPG), glycosylated hemoglobin (HbA1C), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL)], and cognitive function scale (RBANS) (including instant memory, visual span, speech function, etc. Attention, delayed memory) score. The serum levels of Txnip were determined by enzyme linked immunosorbent assay (Elisa) and insulin reduction assay (IR). Results (1) compared with the normal control group, the level of TXN Txnip in T2DM patients increased (P0.05) the activity of Trx decreased (P0.05) and the RBANS scale of T2DM patients had immediate memory, delayed memory, total score decreased (P0.05), and the level of TxTxnip and fasting blood glucose were decreased in T2DM patients. The activity of Txnip was negatively correlated with the activity of Txnip (P0.05) the level of Txnip in serum was negatively correlated with the delayed memory of RBANS (P0.05) and the activity of Trx was positively correlated with the activity of Txnip (P0.05). Conclusion the increase of Txnip in serum and the decrease of Trx activity may be a risk factor for cognitive impairment in patients with T2DM.
【作者单位】：华北理工大学研究生学院;河北省唐山市工人医院内分泌二科;
【基金】：河北省自然科学基金青年基金(No:H2015105083)
【分类号】：R587.1

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