超敏C反应蛋白、内皮抑素在糖尿病肢端坏疽早期病变中的诊断意义

发布时间：2018-06-29 23:04

本文选题：超敏C反应蛋白 + 内皮抑素　；参考：《中国现代医学杂志》2016年18期

【摘要】：目的探讨超敏C反应蛋白(hs-CRP)、内皮抑素(ES)在糖尿病肢端坏疽早期病变(DG)中的诊断价值。方法将106例2型糖尿病患者,按照是否出现糖尿病足分为单纯糖尿病组(DM组)和糖尿病肢端坏疽早期病变组(DG组),采用超敏乳胶增强散射比浊法测定hs-CRP,ELISA法测定ES,检测其在DG中的诊断价值。结果 DG组自主神经病变(DAN)、下肢动脉管病变(LEAD)、微量尿蛋白(MAU)、踝肱指数(ABI)、低密度脂蛋白(LDL-C)、hs-CRP、血管内皮生长因子(VEGF)、ES以及欧米诺变色开始时间、完全变色时间均高于DM组(P0.05或P0.01);Spearman相关性分析发现,hs-CRP与DAN、LEAD、VEGF、ES、LDL-C呈正相关(r=0.486、0.477、0.505、0.503和0.473,P0.05),与ABI呈负相关(r=-0.488,P0.05);ES与DAN、LEAD、VEGF、hs-CRP呈负相关(r=-0.507,-0.501,-0.492和-0.508,P0.05),与ABI呈负相关(r=0.497,P0.05);ES+hs-CRP诊断在敏感性、特异性、阳性预测值、阴性预测值、诊断准确率及AUC均高于ES、hs-CRP单独诊断。结论 ES、hs-CRP与DG以及合并有自主神经病变具有明显相关性,ES联合hs-CRP对于DG具有较高的诊断价值。
[Abstract]:Objective to investigate the diagnostic value of hypersensitive C-reactive protein (hs-CRP) and endostatin (es) in early diabetic limb gangrene (DG). Methods 106 patients with type 2 diabetes, Patients with diabetic foot were divided into simple diabetic group (DM group) and early diabetic limb gangrene lesion group (DG group) according to whether diabetic foot appeared or not. The hypersensitive emulsion enhanced scattering turbidimetry (HS-CRP- Elisa) was used to detect ESG and its diagnostic value in DG was detected. Results in DG group, autonomic neuropathy (Dan), lower extremity arterial canal disease (LEAD), trace urine protein (mau), ankle-brachial index (ABI), low density lipoprotein (LDL-C) hs-CRPs, vascular endothelial growth factor (VEGF) and aminol were observed. The time of complete discoloration was higher than that of DM group (P0.05 or P0.01). The results of Spearman correlation analysis showed that hs-CRP was positively correlated with LDL-C of DANLEADV (r 0.4860.4770.477U 0.505U 0.503 and 0.473P 0.05), and negatively correlated with ABI (r-0.488P0.05). Es and DANLEADVEGFHs-CRP were negatively correlated with DANLEADVEGFHs-CRP (r-0.507mg-0.501- 0.492 and -0.508P0.05), and negatively correlated with ABI (r-0.497P) in the diagnosis of hs-CRP, and negatively correlated with the sensitivity, specificity and predictive value of es and DANLEADVEGFHs-CRP (r-0.507- 0.501- 0.492 and -0.508P0.05), respectively. Negative predictive value, diagnostic accuracy and AUC were higher than ESU hs-CRP alone. Conclusion ESU hs-CRP and DG as well as autonomic neuropathy are significantly correlated with es and hs-CRP in the diagnosis of DG.
【作者单位】：河南大学淮河医院皮肤科;河南大学淮河医院糖尿病科;
【分类号】：R587.2

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