肠内生态免疫营养联合中药归脾汤加减治疗气血两虚型老年营养不良患者的临床研究

发布时间：2018-06-30 21:30

本文选题：生态免疫营养 + 归脾汤　；参考：《浙江中医药大学》2017年硕士论文

【摘要】：目的观察肠内生态免疫营养支持联合中药归脾汤加减治疗老年营养不良患者的临床效果,进一步阐明气血两虚导致老年营养不良的病理实质,丰富中医药治疗虚劳病症的科学内涵。方法将120例老年营养不良患者作为研究对象,按照随机对照原则分为对照组、生态免疫营养组和中药组各40例。根据患者每天能量需要量推算出每日营养液摄入量。对照组给予鼻饲瑞代营养液(500ml/袋,450kcal/500ml);生态免疫组给予鼻饲瑞能营养液(200ml/瓶,260kcal/200ml),鼻饲复方嗜酸乳杆菌片,4片/次,3次/天;中药组给予在生态免疫营养组治疗基础上给予中药归脾汤加减鼻饲治疗,中药浓煎至60ml,每次一剂,2次/天。三组患者均治疗2周。治疗结束后分别从临床疗效、一般情况、中医症候量表评分、生化指标、免疫学指标等情况进行对比分析观察临床疗效。结果1.中药组的小腿围长度较治疗前增加(P=0.025),且其中医症候积分较生态免疫组、对照组比较下降(P0.05)。2.中药组的总白蛋白水平较生态免疫组、对照组明显提高(P=0.003);血红蛋白水平较生态免疫组、对照组明显提高(P=0.043);中药组的总胆固醇水平及甘油三酯水平较治疗前下降,且高密度脂蛋白水平较前升高(P0.05)。3.中药组的IgA水平较生态免疫组、对照组明显提高(P=0.015)。4.中药组肠内营养并发症发生率较生态免疫组、对照组降低,包括腹泻、腹胀等不适。结论肠内生态免疫营养支持联合中药归脾汤能改善患者营养状态,增强机体免疫功能,且中药在治疗慢性疾病有独特优势和良好疗效,副作用低。
[Abstract]:Objective to observe the clinical effect of enteral ecological immune nutrition support combined with traditional Chinese medicine Guipi decoction in the treatment of senile malnutrition, and to further clarify the pathological essence of senile malnutrition caused by deficiency of qi and blood. Enrich the scientific connotation of TCM treatment of asthenia. Methods 120 patients with senile malnutrition were divided into control group, ecological immune nutrition group and traditional Chinese medicine group according to the principle of random control. Daily nutrient intake was calculated according to the patient's daily energy requirement. The control group was given 500ml/ bag 450kcal / 500ml, the ecological immunization group was given 200ml/ 260kcal / 200ml, and the nasal feeding compound Lactobacillus acidophilus tablets 4 times a day. The traditional Chinese medicine group was given traditional Chinese medicine Guipi decoction to 60 ml twice a day on the basis of ecological immune nutrition group. All the patients in the three groups were treated for 2 weeks. At the end of the treatment, the clinical efficacy was compared and analyzed from clinical effect, general situation, TCM symptom scale score, biochemical index, immunological index and so on. Result 1. The leg circumference length of the traditional Chinese medicine group increased compared with that before treatment (P0. 025), and its TCM symptom score was higher than that of the ecological immune group, while the control group decreased (P0.05). 2. The total albumin level in the Chinese medicine group was significantly higher than that in the ecological immunization group and the control group (P0. 003), the hemoglobin level in the traditional Chinese medicine group was significantly higher than that in the ecological immunization group (P0. 043), the total cholesterol level and triglyceride level in the Chinese medicine group were lower than those before treatment. The level of high density lipoprotein was higher than that before (P0.05). 3. The IgA level in the Chinese medicine group was significantly higher than that in the ecological immunization group and the control group (P0. 015). 4. 4. The incidence of enteral nutrition complications in the Chinese medicine group was lower than that in the ecological immunization group and the control group, including diarrhea, abdominal distension and other discomfort. Conclusion Eco-immune nutrition support combined with Guipi decoction can improve the nutritional status of the patients and enhance the immune function of the patients. The traditional Chinese medicine has unique advantages and good efficacy in the treatment of chronic diseases with low side effects.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R591

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