基于广义OR的脂联素基因外显子rs2241766多态性与中国人群糖尿病易感性的关联分析

发布时间：2018-07-01 15:10

本文选题：脂联素基因 + rs　；参考：《郑州大学学报(医学版)》2017年06期

【摘要】：目的:探索中国人群脂联素基因外显子rs2241766多态性与糖尿病易感性的关系。方法:全面检索国内外数据库,搜集有关中国人群的符合纳入和排除标准的文献。根据糖尿病组与对照组人群脂联素基因rs2241766位点GG、GT和TT 3种基因型频数,使用无遗传模式法的广义OR值(GOR)评价该位点多态性与糖尿病的关联性。结果:共纳入文献41篇。糖尿病患者7 142例,对照组6 588例。研究间存在异质性(I~2=76.30%,P0.001),故选择随机效应模型,GOR(95%CI)为1.16(1.01~1.31),提示rs2241766位点G等位基因是中国人群糖尿病患病危险因素。Meta回归分析结果表明糖尿病组平均年龄和样本量是异质性主要来源,研究无发表偏倚,敏感性分析也表明结果稳定。结论:rs2241766位点G等位基因是中国人群糖尿病患病危险因素。
[Abstract]:Objective: to investigate the association between rs2241766 polymorphism of adiponectin gene exon and susceptibility to diabetes mellitus in Chinese population. Methods: to search the domestic and foreign databases and collect the literature about the inclusion and exclusion criteria of Chinese population. According to the frequency of three genotypes of adiponectin gene rs2241766 locus (GGG GT and TT) in diabetic group and control group, the association between the polymorphism and diabetes mellitus was evaluated by the generalized OR value (GOR) without genetic model method. Results: 41 articles were included. There were 7 142 cases of diabetes mellitus and 6 588 cases of control group. There was heterogeneity among the studies (IX276.30 + P0.001), so the random effect model (95CI) was 1.16 (1.01m1.31), suggesting that the G allele at rs2241766 locus was the risk factor of diabetes mellitus in Chinese population. Meta regression analysis showed that the mean age and sample size of diabetic group were the main sources of heterogeneity. There was no publication bias and sensitivity analysis showed that the results were stable. Conclusion the G allele at 1: rs2241766 is a risk factor for diabetes in Chinese population.
【作者单位】：郑州大学公共卫生学院卫生统计学教研室郑州大学基础医学院组织学与胚胎学教研室
【基金】：国家自然科学基金项目81001280,81202277 河南省高等学校重点科研项目计划16A330003 河南省科技攻关计划项目172102310373
【分类号】：R587.1

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