糖尿病勃起功能障碍的机制及治疗进展

发布时间：2018-07-04 10:12

本文选题：糖尿病 + 勃起功能障碍　；参考：《河北医科大学》2017年硕士论文

【摘要】：糖尿病已成为全球人类健康最大的威胁之一。勃起功能障碍是糖尿病并发症之一,占糖尿病男性病人75%。随着糖尿病患病人数的增加,糖尿病并发症的患病人数也必然随之增加,其中勃起功能障碍(Erectile dysfunction,ED)是与糖尿病关系最为密切并且严重影响患者生活质量的并发症之一。由于其复杂的病因,糖尿病ED是很难治愈的,并且对5磷酸二酯酶(Phosphodiesterase type 5,PDE5)受体阻滞剂(一线口服药物)疗效欠佳。更加深入的了解糖尿病ED的分子机制,对于探索新型疗法异常重要。而糖尿病ED的发病机制又是多因素的,涉及内皮细胞功能障碍、NO/CGMP通路、RhoA/Rho激酶通路、高胰岛素血症与氧化应激、糖基化终末产物等。因此在糖尿病的临床诊治过程中,了解糖尿病勃起功能障碍的机制、重视ED的治疗对于改善预后、提高患者生活质量有着重要意义。
[Abstract]:Diabetes has become one of the greatest threats to human health in the world. Erectile dysfunction is one of the complications of diabetes, accounting for 75 diabetes patients with diabetes. With the increase of the number of diabetic patients, the number of diabetic complications will inevitably increase. Among them, erectile dysfunction (Ed) is one of the most closely related to diabetes and seriously affects the quality of life of patients with complications. Diabetic Ed is difficult to cure because of its complicated etiology, and the efficacy of Phosphodiesterase type 5 PDE5 receptor blocker (first-line oral drug) is poor. A deeper understanding of the molecular mechanisms of diabetic Ed is important for exploring new therapies. The pathogenesis of diabetic Ed is multifactorial, involving endothelial cell dysfunction and no / CGMP pathway, RhoA / Rho kinase pathway, hyperinsulinemia and oxidative stress, glycosylation end products and so on. Therefore, in the clinical diagnosis and treatment of diabetes mellitus, it is important to understand the mechanism of diabetic erectile dysfunction and pay attention to the treatment of Ed to improve the prognosis and improve the quality of life of patients.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2;R698

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