强直性脊柱炎动物模型归类及其机制研究与进展

发布时间：2018-07-04 21:15

本文选题：脊柱炎 + 强直性　；参考：《中国组织工程研究》2017年11期

【摘要】：背景:强直性脊柱炎是以侵犯中轴关节为主的慢性炎症自身免疫性疾病,目前发病机制仍不明确。需要进行深入的研究,稳定和成熟的动物模型显得更加重要。强直性脊柱炎脊柱和骶髂生物样本非常的稀缺,然而学者们对该病发病机制的理解很大程度上依赖于强直性脊柱炎动物模型的研究成果,目前的几种强直性脊柱炎动物模型均无法很好的代表强直性脊柱炎的病理病程。目的:通过总结以往各类强直性脊柱炎动物模型临床和病理特征,为进一步完善此类动物模型提供基础。方法:以("Ankylosing Spondylitis"AND"Animal Models")OR("HLA-B27"AND"Animal models")为英文检索词,以("强直性脊柱炎"AND"动物模型"OR("人类白细胞抗原B27"AND"动物模型")为中文检索词,通过检索Pub Med/CNKI数据库,排除临床新药研究、动物模型仅为研究手段及未涉及动物模型机制探讨的文章。对目前常见的强直性脊柱炎动物模型发病机制、病理特征进行归纳总结。结果与结论:纳入综述的文章为37篇。把目前现有的几种强直性脊柱炎动物模型归为3大类,各类动物模型各有其优缺点,它们均能模拟强直性脊柱炎的某些发病特征,但是仍缺乏强直性脊柱炎最具代表性的动物模型,考虑到强直性脊柱炎的发病与肠道菌群密切相关,并将各类动物模型的发病特与之结合,有望复制出更加稳定和完善的强直性脊柱炎动物模型。
[Abstract]:Background: ankylosing spondylitis (ankylosing spondylitis) is a chronic autoimmune disease which mainly invades the axial joint. The pathogenesis of ankylosing spondylitis is still unclear. Stable and mature animal models need to be studied in depth. The spine and sacroiliac biological samples of ankylosing spondylitis are scarce, but scholars' understanding of the pathogenesis of the disease depends to a large extent on the results of animal models of ankylosing spondylitis. Several animal models of ankylosing spondylitis can not represent the pathological course of ankylosing spondylitis. Objective: to summarize the clinical and pathological features of various animal models of ankylosing spondylitis. Methods: using "Ankylosing Spondylitis" and "Animal models" OR ("HLA-B27" and "Animal models") as the English key word, or (the animal model of "ankylosing spondylitis" and "animal model of human leukocyte antigen B27" and "animal model of human leukocyte antigen B27") as the Chinese key word. Animal model is only a research method and does not involve the discussion of animal model mechanism. The pathogenesis and pathological features of common animal models of ankylosing spondylitis were summarized. Results & conclusion: 37 articles were included in the review. The present animal models of ankylosing spondylitis are classified into three categories. Each animal model has its own advantages and disadvantages, and they can all simulate some characteristics of ankylosing spondylitis. However, there is still a lack of the most representative animal models of ankylosing spondylitis. Considering that the incidence of ankylosing spondylitis is closely related to the intestinal flora, It is expected to replicate a more stable and perfect animal model of ankylosing spondylitis.
【作者单位】：广州中医药大学第二临床医学院;广东省中医药科学院;广东省中医院新药开发办;
【基金】：国家自然科学基金资助项目(81273736,81673898)~~
【分类号】：R-332;R593.23

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