强直性脊柱炎患者骨密度及骨代谢标志物的变化

发布时间：2018-07-07 16:45

  本文选题：脊柱炎 + 强直性　； 参考：《中国骨质疏松杂志》2016年01期

【摘要】：目的观察强直性脊柱炎(AS)患者骨密度(BMD)及骨代谢标志物的变化。方法 AS组:2013年1月-2015年2月,52例,男40例、女12例,年龄(32.33±13.51)岁;健康对照组:50例,男38例、女12例,年龄(31.52±11.87)岁。检测双股骨颈、腰椎1-4BMD与T值;血清骨钙素(BGP)、I型原胶原氨基端前肽(PINP)、I型胶原C-末端肽(CTX);AS组检测C-反应蛋白(CRP)、血沉(ESR),计算病情活动指数(BASDAI)及功能指数(BASFI)。采用t检验与相关分析。结果 (1)AS组男、女性双股骨颈BMD(0.943±0.163,0.940±0.148)低于对照组(1.179±0.142,1.176±0.141);腰椎1-4BMD(1.057±0.179,1.069±0.187)低于对照组(1.199±0.121,1.202±0.166);(2)AS组双股骨颈、腰椎1-4骨质疏松及骨量减少分别是57.69%和61.53%;(3)AS组双股骨颈、腰椎1-4BMD与BASDAI呈负相关性(r=-0.426、-0.478)(P0.05);(4)AS组男、女性BGP含量(13.47±4.36、13.85±3.75)低于对照组(21.57±3.18、20.77±4.19)(P0.05),PINP含量(24.47±3.53、23.66±4.73)低于对照组(32.25±4.33、31.17±3.20)(P0.05),CTX含量(0.80±0.13、0.74±0.17)高于对照组(0.37±0.10、0.37±0.13)(P0.05);(5)AS组BGP与双股骨颈、腰椎1-4BMD呈正相关性(r=0.475、0.431)(P0.05),CTX呈负相关性(r=-0.516、-0.466)(P0.05)。结论 AS患者存在BMD降低,BGP、PINP含量减少,CTX增加,导致骨质疏松,应采取防治措施。
[Abstract]:Objective to observe the changes of bone mineral density (BMD) and bone metabolic markers in patients with ankylosing spondylitis (as). Methods from January 2013 to February 2015, 52 patients (male 40, female 12, age (32.33 卤13.51) years) and healthy control group (50 cases, 38 males and 12 females, aged (31.52 卤11.87) years) were enrolled in as group. Serum osteocalcin (BGP) type I procollagen C-terminal peptide (PINP) and type I collagen C-terminal peptide (CTX) were measured for C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), disease activity index (BASDAI) and function index (BASFI) in patients with double femoral neck and lumbar vertebrae. T test and correlation analysis were used. 缁撴灉 (1)AS缁勭敺,濂虫，

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