RASFs在类风湿性关节炎发病机制中的作用及其激活机制

发布时间：2018-07-07 22:17

本文选题：滑膜成纤维细胞 + 类风湿性关节炎　；参考：《江苏农业学报》2017年01期

【摘要】：类风湿性关节炎(RA)是一种复杂的自身免疫性疾病,其发病机制十分复杂。滑膜组织的增生是该病的主要病理变化之一。大量科学研究结果表明,在类风湿性关节炎疾病的发生和发展过程中,激活的滑膜成纤维细胞(SFs)具有特殊的增殖特性,并在炎症反应、血管新生以及组织破坏等方面扮演重要角色。本文对滑膜成纤维细胞在类风湿性关节炎发生发展过程中的重要作用及其激活机制的研究进展进行分析和讨论,为认识类风湿性关节炎发病机制提供参考。
[Abstract]:Rheumatoid arthritis (RA) is a complex autoimmune disease, its pathogenesis is very complex. Synovial hyperplasia is one of the main pathological changes of the disease. A large number of scientific studies have shown that activated synovial fibroblasts (SFs) have special proliferative properties during the occurrence and development of rheumatoid arthritis, and in the inflammatory response. Angiogenesis and tissue damage play an important role. In this paper, the important role of synovial fibroblasts in the occurrence and development of rheumatoid arthritis and its activation mechanism are analyzed and discussed in order to provide a reference for understanding the pathogenesis of rheumatoid arthritis.
【作者单位】：重庆三峡职业学院;
【基金】：重庆市教委科技项目(KJ1503406)
【分类号】：R593.22

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