牙周炎与骨质疏松症相关性的Meta分析

发布时间：2018-07-08 12:27

本文选题：牙周炎 + 牙周病　；参考：《华北理工大学》2017年硕士论文

【摘要】：目的目前国内外文献对于牙周炎与骨质疏松症的关系尚不明确,本研究的目的是通过Meta分析寻找最佳证据系统评价牙周炎与骨质疏松症的关系。方法检索1989~2016年在PubMed、The Cochrane Library、CBM、CNKI、万方数据库中发表的有关牙周炎和骨质疏松症的相关文献,语言是英语和汉语。2名研究者分别按照纳入和排除标准进行文献筛选、质量评价、数据提取,采用Revman5.3软件进行数据分析并绘制森林图,效应指标是OR值或MD和95%CI,漏斗图评价发表偏倚。结果共检索到406篇文献,初步纳入59篇,全文阅读后最终纳入18篇文献,合计5315例研究对象,其中病例组2017例,对照组3298例。5项研究合并统计量,研究结果表明:牙周炎组发生骨质疏松症的概率高于非牙周炎组(OR=1.71,95%CI[1.31,2.23],P0.0001);8项研究合并分析结果显示:骨质疏松症组发生牙周炎的概率大于非骨质疏松症组(OR=1.81,95%CI[1.45,2.27],P0.00001);骨质疏松症组与非骨质疏松症组在牙齿保留数量上存在显著的统计学差异(MD=-1.30,95%CI[-1.94,-0.65],P0.0001);在骨质疏松症组与非骨质疏松症组中,PD和BOP无显著性差异(分别为MD=-0.05,95%CI[-0.15,0.06],P=0.38、MD=3.83,95%CI[-2.11,9.77],P=0.21),而骨质疏松症组人群比非骨质疏松症组人群有更显著的CAL、GR和ABL(分别为MD=0.29,95%CI[0.12,0.46],P=0.001、MD=0.46,95%CI[0.20,0.71],P=0.0004和MD=0.18,95%CI[0.06,0.29],P=0.003);与非骨质疏松症组相比,骨质疏松症组与绝经时间有显著的统计学意义(MD=3.28,95%CI[2.43,4.12],P0.00001)。结论1骨质疏松症是牙周炎的一个危险因素,牙周炎也是骨质疏松症的一个危险因素。2与非骨质疏松症组相比,骨质疏松症组有更显著的牙丧失、牙槽骨丧失、临床附着丧失和牙龈萎缩,而与牙周探诊深度和探诊出血无关,骨质疏松症组的绝经时间大于非骨质疏松症组。
[Abstract]:Objective to evaluate the relationship between periodontitis and osteoporosis by meta-analysis, the relationship between periodontitis and osteoporosis is not clear in domestic and foreign literature. Methods the literature on periodontitis and osteoporosis published in PubMeden the Cochrane Library, CNKI, Wanfang database from 1989 to 2016 was searched. The language was English and Chinese, which were used to screen the literature, evaluate the quality and extract the data according to the inclusion and exclusion criteria, respectively. Using Revman 5.3 software to analyze data and draw forest map, the effect index is OR or MD and 95 CI, and the bias of funnel map evaluation is published. Results A total of 406 articles were retrieved, 59 were preliminarily included, and 18 articles were included after reading. A total of 5315 subjects were included, including 2017 cases in the case group and 3298 cases in the control group. The results showed that the incidence of osteoporosis in the periodontitis group was higher than that in the non-periodontitis group (OR1.71 ~ 95CI [1.31 / 2.23] / P 0.0001). The combined analysis of 8 studies showed that the incidence of periodontitis in the osteoporosis group was higher than that in the non-osteoporosis group (OR1.8195CI [1.452.27] P0.00001), and that in the osteoporosis group the incidence of periodontitis was higher than that in the non-osteoporosis group (OR1.8195CI [1.452.27] P0.00001). There was a significant difference in the number of teeth retention between the two groups (MD-1.3095 CI [-1.94- 0.65] P 0.0001), but there was no significant difference between osteoporosis group and non-osteoporosis group (MD-0.0595CI [-0.15595 CI [-0.15595 CI [-0.38 MDT 3.8395CI [-2.1149.77] P0.21]), but there was no significant difference between osteoporosis group and non-osteoporosis group (MD-0.0595CI [-0.15595 CI [-1.3095 CI [-2.1149.77] P0.21]. There were more significant CALGR and ABL in the osteoporosis group (MD0.2995CI [0.120.46] P0.001MD0.69595 CI [0.200.71] CI 0.0004 and MDO0.180.29 CI [0.060.29] P0.003). There was significant statistical difference between osteoporosis group and menopausal time (MDT 3.2895 CI [2.43 4.12] P 0.00001). Conclusion (1) Osteoporosis is a risk factor of periodontitis, and periodontitis is also a risk factor of osteoporosis. Clinical attachment loss and gingival atrophy were not related to the depth of periodontal diagnosis and bleeding. The menopause time of osteoporosis group was longer than that of non-osteoporosis group.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R580;R781.42

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