脂肪因子在自身免疫发生与调节中的作用

发布时间：2018-07-12 18:51

本文选题：脂肪因子类 + 自身免疫疾病　；参考：《中国组织工程研究》2017年16期

【摘要】：背景:脂肪因子是一类由脂肪组织分泌的生物介质,所分泌和影响的一系列细胞因子和趋化因子。近年来,研究发现脂肪因子在促炎和抗炎调节中也起到了一定的作用。目的:分析不同类型脂肪因子在自身免疫反应及免疫疾病中的炎症调节作用,以期提出控制自身免疫疾病的进展并有效治疗疾病的策略,寻找评估病情的进展、并发症的发生以及预测患者的生存预后的有效指标。方法:以"脂肪因子,自身免疫"和"adipokine,autoimmune"为检索词,检索1986至2016年中国知网和Pub Med数据库,查询脂肪因子在自身免疫中作用的相关文献。结果与结论:脂肪组织不只在调节代谢功能中扮演了重要角色,对脂肪组织的认知随着脂肪因子对调节免疫反应的作用而不断发展。脂肪因子在机体中发挥了多种作用,对代谢和炎症有广泛的影响。自身免疫性疾病的发生仍有一部分是某些尚未明确的炎症应答因素,而随着对脂肪因子的研究不断深入,将会对自身免疫疾病的机制研究做出重大突破。
[Abstract]:Background: aliphatic factors are a class of biological mediators secreted by adipose tissue, which secrete and affect a series of cytokines and chemokines. In recent years, studies have found that fat factors also play a role in proinflammatory and anti-inflammatory regulation. Objective: to analyze the role of different types of fat factors in the regulation of autoimmune response and immune diseases, so as to put forward strategies to control the progress of autoimmune diseases and to effectively treat diseases, and to find out ways to evaluate the progress of the disease. The occurrence of complications and the effective indicators to predict the survival and prognosis of patients. Methods: using "adipokinesis-autoimmune" and "adipokinesis-autoimmune" as the key words, we searched the database of Chinese knowledge Network and Pub Med from 1986 to 2016, and inquired about the related literatures on the role of fat factors in autoimmunity. Results & conclusion: adipose tissue not only plays an important role in regulating metabolic function, but also the cognition of adipose tissue develops with the effect of fat factor on regulating immune response. Fat factors play a variety of roles in the body, and have a wide range of effects on metabolism and inflammation. The occurrence of autoimmune diseases is still a part of some undefined inflammatory response factors, but with the in-depth study of fat factors, it will make a major breakthrough in the mechanism of autoimmune diseases.
【作者单位】：上海长征医院研究生队;上海长征医院脊柱二科;上海长征医院麻醉科;上海长征医院内科教研室;
【基金】：国家自然科学基金项目(81271351,81371253) 第二军医大学大学生创新基金(ZD2016010,MS2016058,FH2016171,FH2016180)~~
【分类号】：R593.2

【参考文献】