亚临床甲状腺功能异常血清胱抑素C和同型半胱氨酸测定的临床意义

发布时间：2018-07-13 07:49

【摘要】：探讨亚临床甲状腺功能异常患者血清胱抑素C(CysC)和同型半胱氨酸(Hcy)的相关性。选择亚临床甲状腺功能亢进(亚甲亢组)60例、亚临床甲状腺功能减退(亚甲减组)120例和对照组60例,测定血清TH、血脂、CysC和Hcy,计算血脂比值并进行分析。结果显示,亚甲亢组TC、TG、LDL-D、LDL-C/HDL-C和LCI降低,以LCI降低最显著,HDL-D、TC/HDL-C、TG/HDL-C和non-HDL-C明显高于对照组,亚甲减组TC、TG和LDL-D、LDL-C/HDL-C和non-HDL-C高于对照组,HDL-D低于对照组,亚甲亢组CysC明显升高,而Hcy降低(P0.05),亚甲减组CysC降低,而Hcy明显升高。因此,动态监测TSH、血脂比值、CysC和Hcy,对亚临床甲状腺功能异常向甲状腺功能异常的转化及其并发CHD的预测有重要的价值,联合检测有望成为理想的优化组合项目。
[Abstract]:To investigate the correlation between serum cystatin C (CysC) and homocysteine (Hcy) in patients with subclinical thyroid dysfunction. Sixty patients with subclinical hyperthyroidism (hyperthyroidism group), 120 patients with subclinical hypothyroidism (subhypothyroidism group) and 60 control group (control group) were selected. The results showed that the levels of LDL-C / LDL-HDL-C and LCI in hyperthyroidism group were significantly lower than those in control group. The levels of TCTG and LDL-DLDL-C / HDL-C and non-HDL-C in hypothyroidism group were significantly higher than those in control group, while CysC in hyperthyroidism group was significantly higher than that in subthyroidism group, but Hcy was decreased (P < 0.05), and CysC in hypothyroidism group was lower than that in subthyroidism group. But Hcy increased obviously. Therefore, dynamic monitoring of TSHs, the ratio of serum lipids, CysC and Hcyhas important value in the transformation of subclinical thyroid dysfunction to thyroid dysfunction and the prediction of CHD, and the combined detection is expected to be an ideal optimal combination.
【作者单位】：沧州医学高等专科学校甲状腺疾病研究所;河北省沧州中西医结合医院实验诊断科;沧州医学高等专科学校附属人民医院外科;沧州医学高等专科学校;
【基金】：2014年沧州医学高等专科学校甲状腺疾病临床研究创新团队和甲状腺疾病研究所自然科学课题(No.14Z001) 2014年河北省科技计划基金项目(No.15277796D)
【分类号】：R581

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