狼疮性膀胱炎的临床特征及危险因素分析
发布时间：2018-07-15 20:37
【摘要】：目的分析狼疮性膀胱炎患者的临床特征及危险因素。方法选取27例确诊的狼疮性膀胱炎的住院患者作为病例组,并选取性别、年龄及病程相匹配的无狼疮性膀胱炎的系统性红斑狼疮(SLE)住院患者共135例作为对照组,回顾性分析两组间临床表现、实验室检查与影像学的差异;通过Logistic回归分析初步探讨狼疮性膀胱炎的危险因素。结果狼疮性膀胱炎的发生率1.3%,主要表现为下尿路症状、双侧输尿管扩张及肾积水等;与对照组相比,狼疮性膀胱炎患者的胃肠道症状的发生率高于无狼疮性膀胱炎的患者,但狼疮性肾炎和蛋白尿的发生率低于后者,差异有统计学意义(P0.05);SLE合并狼疮性膀胱炎组患者补体低于对照组,抗SSA抗体的阳性率高于对照组(P0.05);狼疮性膀胱炎组SLEDAI评分低于对照组(P0.05);Logistic回归分析发现胃肠道症状、低补体为狼疮性膀胱炎的危险因素。结论胃肠道症状及低补体为狼疮性膀胱炎的危险因素,抗SSA抗体与狼疮性膀胱炎密切相关。
[Abstract]:Objective to analyze the clinical characteristics and risk factors of lupus cystitis patients. Methods 27 hospitalized patients with lupus cystitis were selected as a case group, and 135 patients with systemic lupus erythematosus (SLE) without lupus cystitis (SLE) were selected as the control group. The retrospective analysis of the two groups was used as a control group. The difference in bed performance, laboratory examination and imaging; the risk factors for lupus cystitis were preliminarily studied by Logistic regression analysis. Results the incidence of lupus cystitis was 1.3%, mainly characterized by lower urinary tract symptoms, bilateral ureteral dilatation and hydronephrosis, compared with the control group, and the occurrence of gastrointestinal symptoms in patients with lupus cystitis. The rate was higher than the patients without lupus cystitis, but the incidence of lupus nephritis and proteinuria was lower than the latter, the difference was statistically significant (P0.05); SLE combined with lupus cystitis group was lower than the control group, the positive rate of anti SSA antibody was higher than that of the control group (P0.05); the SLEDAI score of the lupus cystitis group was lower than the control group (P0.05); Logistic returns to the group of lupus cystitis group (P0.05); Gastrointestinal symptoms and low complement are the risk factors for lupus cystitis. Conclusion gastrointestinal symptoms and low complement are risk factors for lupus cystitis. Anti SSA antibody is closely related to lupus cystitis.
【作者单位】： 中南大学湘雅医院风湿免疫科;
【基金】：2015年度“湘雅医院-北大未名临床与康复研究基金”(No:xywm2015118)
【分类号】：R593.24;R694.3
本文编号：2125310
[Abstract]:Objective to analyze the clinical characteristics and risk factors of lupus cystitis patients. Methods 27 hospitalized patients with lupus cystitis were selected as a case group, and 135 patients with systemic lupus erythematosus (SLE) without lupus cystitis (SLE) were selected as the control group. The retrospective analysis of the two groups was used as a control group. The difference in bed performance, laboratory examination and imaging; the risk factors for lupus cystitis were preliminarily studied by Logistic regression analysis. Results the incidence of lupus cystitis was 1.3%, mainly characterized by lower urinary tract symptoms, bilateral ureteral dilatation and hydronephrosis, compared with the control group, and the occurrence of gastrointestinal symptoms in patients with lupus cystitis. The rate was higher than the patients without lupus cystitis, but the incidence of lupus nephritis and proteinuria was lower than the latter, the difference was statistically significant (P0.05); SLE combined with lupus cystitis group was lower than the control group, the positive rate of anti SSA antibody was higher than that of the control group (P0.05); the SLEDAI score of the lupus cystitis group was lower than the control group (P0.05); Logistic returns to the group of lupus cystitis group (P0.05); Gastrointestinal symptoms and low complement are the risk factors for lupus cystitis. Conclusion gastrointestinal symptoms and low complement are risk factors for lupus cystitis. Anti SSA antibody is closely related to lupus cystitis.
【作者单位】： 中南大学湘雅医院风湿免疫科;
【基金】：2015年度“湘雅医院-北大未名临床与康复研究基金”(No:xywm2015118)
【分类号】：R593.24;R694.3
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1 ;胃肠道症状提示狼疮性膀胱炎[J];中国社区医师;2011年10期
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