药源性疾病原因调查及与中药相关性研究

发布时间：2018-07-17 07:34

【摘要】：目的:阐析药源性疾病(DID)的发病原因,即不同种类的药物,特别是中药在DID发病中的发生情况。方法:将临床诊疗中发现的58例DID住院患者的原因进行详尽调查,然后将用药与DID进行相关性分析,总结DID的发病原因。判定DID依据,排除可能的疾病因素,DID发病与用药在时间上有相关性,用药时发病或病情加重,停药病情好转或正常。结果:DID患者平均年龄67.2岁。患有1种慢性疾病的15例,患有2种以上慢性疾病的39例,共计54例,占93.1%。人均用药5.7种。用药持续时间从2d至30年。58例中有肝损害20例,消化道出血28例,共47例,占81.0%。解热镇痛药致DID共32例,占55.2%。1例DID为中药所致,占1.7%。结论:DID患者以老年多病者为多。DID调查分析其归因时要全面、慎重。解热镇痛药是DID的主要原因,中药占比不高。
[Abstract]:Objective: to analyze the pathogenesis of drug-induced disease (did), that is, the occurrence of different kinds of drugs, especially traditional Chinese medicine (TCM). Methods: the causes of 58 inpatients with Did were investigated in detail, and then the correlation between Did and Did was analyzed, and the causes of Did were summarized. There was a correlation between the onset of Did and the time of medication, the onset or aggravation of the disease, the improvement of the condition or the normal state of the drug when the drug was taken. Results the average age of the patients was 67.2 years old. There were 15 cases of one kind of chronic disease and 39 cases of more than 2 kinds of chronic diseases, 54 cases (93.1%). There are 5.7 kinds of drugs per capita. From 2 days to 30 years, there were 20 cases of liver damage, 28 cases of gastrointestinal hemorrhage, 47 cases (81.0%). There were 32 cases of Did caused by antipyretic analgesics, of which 55.2 cases were caused by traditional Chinese medicine (1.7%). Conclusion it is necessary to be comprehensive and careful in the investigation and analysis of the attributions of the patients with the disease in the elderly. Antipyretic analgesics are the main reason of did, the proportion of traditional Chinese medicine is not high.
【作者单位】：上海市金山区亭林医院药剂科;复旦大学附属金山医院药剂科;
【分类号】：R595.3

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