类风湿关节炎患者发生骨质疏松性椎体压缩性骨折的危险因素分析

发布时间：2018-07-23 19:30

【摘要】：目的探讨类风湿关节炎(RA)患者发生骨质疏松性椎体压缩性骨折的危险因素。方法以200例RA患者为研究对象,其中发生骨质疏松性椎体压缩性骨折34例(骨折组),未发生166例(非骨折组)。比较两组年龄、病程、激素使用时间、激素累积使用量、血沉(ESR)、CRP、抗环瓜氨酸多肽抗体(抗CCP抗体)、28个关节疾病活动指数(DAS28),采用SPSS19.0软件对上述资料进行单因素和多因素Logistic回归分析。结果单因素分析结果显示,两组年龄、病程、激素使用时间、激素累积使用量及ESR比较P均0.05,性别、CRP、抗CCP抗体及DAS28比较P均0.05。多因素Logistic回归分析结果显示,年龄≥65岁、病程7 a、激素使用时间300 d、激素累积使用量2 500 mg、ESR50 mm/h为RA患者发生骨质疏松性椎体压缩性骨折的独立危险因素(P均0.05)。结论高龄、病程长、激素使用时间长、激素累积使用量大、ESR升高是RA患者发生骨质疏松性椎体压缩性骨折的危险因素。
[Abstract]:Objective to investigate the risk factors of osteoporotic vertebral compression fracture in patients with rheumatoid arthritis (RA). Methods 200 patients with RA were studied. 34 cases of osteoporotic vertebral compression fracture (fracture group) and 166 cases of no fracture group (non-fracture group) were studied. Age, course of disease, duration of hormone use, cumulative use of hormone were compared between the two groups. Erythrocyte sedimentation rate (ESR), anti-cyclic citrulline polypeptide antibody (CCP antibody), and 28 joint disease activity index (DAS28) were analyzed by single factor and multivariate Logistic regression with SPSS19.0 software. Results the results of univariate analysis showed that the age, course of disease, time of hormone use, the amount of hormone used and the ratio of ESR were all 0.05, and the sex of CRP, anti CCP antibody and DAS28 were all 0.05. The results of multivariate Logistic regression analysis showed that age 鈮，

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