真菌致敏哮喘患者的临床特征

发布时间：2018-07-24 18:28

【摘要】：目的分析哮喘患者真菌致敏的情况及其临床特征。方法哮喘患者行血清霉菌Ig E检测及变应原皮肤点刺试验,筛选出伴真菌致敏的哮喘患者,比较分析真菌致敏患者与不伴真菌致敏患者的临床特征。结果112例哮喘患者分为两组,26例患者血清霉菌Ig E和(或)霉菌皮肤点刺试验阳性,为真菌致敏组,余下86例为不伴真菌致敏组。真菌致敏组年龄明显低于不伴真菌致敏组(P=0.004);前者的重度哮喘患者比例高于后者(P=0.032);前者同时存在多种变应原致敏的比例明显高于后者(P0.001);两组患者性别、合并变应性鼻炎和(或)皮炎比例、血清总Ig E、外周血嗜酸性粒细胞计数、第1秒用力呼气容积占预计值%(FEV1%)差异无统计学意义(P0.05)。结论真菌为诱发哮喘的常见变应原之一,伴真菌致敏的哮喘患者平均年龄低、重度哮喘比例高,且常存在对多种变应原敏感的情况。
[Abstract]:Objective to analyze the fungal sensitization and its clinical characteristics in asthmatic patients. Methods Asthma patients were tested with mycetes IgE and allergen skin prick test. The clinical characteristics of fungal sensitization patients and those without fungal sensitization were compared and analyzed. Results 112 asthmatic patients were divided into two groups: 26 patients were positive for mycetes IgE and / or fungal skin prick test, the other 86 patients were without fungal sensitization group. The age of fungal sensitization group was significantly lower than that of non-fungal sensitization group (P0. 004), the proportion of severe asthma patients in the former group was higher than that in the latter group (P0. 032), and the proportion of allergen allergens in the former group was significantly higher than that in the latter group (P0. 001). There was no significant difference in the proportion of allergic rhinitis and / or dermatitis, total serum Ig E, eosinophil count in peripheral blood and forced expiratory volume (FEV1%) in 1 second (P0.05). Conclusion fungus is one of the common allergens to induce asthma. The average age of asthmatic patients with fungal sensitization is low, the proportion of severe asthma is high, and the allergen is often sensitive to many kinds of allergens.
【作者单位】：广州医科大学附属第二医院呼吸科;广州医科大学;广州医科大学附属第二医院过敏反应科;
【基金】：广州医科大学博士启动项目(编号:2013C52)
【分类号】：R562.25

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