苍附导痰汤联合氯米芬对多囊卵巢综合征合并不孕症患者性激素水平及子宫内膜容受性的影响

发布时间：2018-07-25 07:20

【摘要】：目的:探讨苍附导痰汤联合枸橼酸氯米芬胶囊对多囊卵巢综合征(PCOS)合并不孕症患者血清性激素水平及子宫内膜容受性的影响。方法:选取2014年1月-2014年12月在贵阳中医学院第一附属医院确诊为PCOS合并不孕症的患者116例,按照随机数字表法分为观察组和对照组,各58例。两组患者均于月经第5天起给予调节激素水平治疗,对照组同时给予枸橼酸氯米芬胶囊50 mg,qd;观察组患者在对照组基础上加服苍附导痰汤1剂,水煎取汁400 mL,bid,两组患者均治疗3个月经周期。比较两组患者治疗前后血清性激素水平[雌二醇(E_2)、黄体生成素(LH)]、子宫内膜厚度(Em)、子宫内膜螺旋动脉搏动指数(PI)、阻力指数(RI),随访1年比较两组患者排卵率及妊娠率。结果:治疗前,两组患者E_2、LH、Em、PI、RI比较,差异均无统计学意义(P0.05);治疗后,两组患者E_2、LH、Em水平显著升高,PI、RI显著降低,且观察组显著优于对照组,差异均有统计学意义(P0.05)。随访1年,两组患者排卵率(77.59%vs.72.41%)比较,差异无统计学意义(P0.05);观察组患者妊娠率为41.38%,显著高于对照组的22.41%,差异有统计学意义(P0.05)。结论:苍附导痰汤联合枸橼酸氯米芬胶囊能有效调节PCOS合并不孕症患者的血清性激素水平,改善子宫内膜容受性,从而提高妊娠率。
[Abstract]:Objective: to investigate the effect of Cangfu Doduantan decoction combined with clomiphene citrate capsule on serum sex hormone level and endometrial receptivity in patients with polycystic ovary syndrome (PCOS) complicated with infertility. Methods: from January 2014 to December 2014, 116 patients with PCOS combined with infertility were selected and divided into observation group (n = 58) and control group (n = 58) in the first affiliated Hospital of Guiyang College of traditional Chinese Medicine from January 2014 to December 2014. The patients in both groups were treated with regulating hormone level from the 5th day of menstruation, the control group was treated with clomiphene citrate capsule 50 mg / g QD, and the patients in the observation group were treated with Cangfu Duan phlegm decoction 1 dose on the basis of the control group. The patients in both groups were treated for 3 menstrual cycles. The serum sex hormone levels (estradiol 2, luteinizing hormone (LH), endometrial thickness (Em), endometrial spiral artery pulsatility index (PI), resistance index) and (PI), resistance index (RI),) were compared before and after treatment between the two groups for one year, and the ovulation rate and pregnancy rate were compared between the two groups. Results: before treatment, there was no significant difference between the two groups (P 0.05), but after treatment, the level of E2LHHN Em in the two groups was significantly higher than that in the control group (P0.05), and the observation group was significantly better than the control group (P0.05). The rate of ovulation in the two groups (77.59v s.72.41%) was not significantly different (P0.05), and the pregnancy rate in the observation group was 41.38, which was significantly higher than that in the control group (22.41) (P0.05). Conclusion: Cangfu Doutan decoction combined with clomiphene citrate capsule can effectively regulate the level of serum sex hormone in PCOS patients with infertility, improve endometrial receptivity and increase pregnancy rate.
【作者单位】：重庆三峡医药高等专科学校中医系;贵阳中医学院第一附属医院妇科;
【分类号】：R711.6;R711.75

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