2型糖尿病患者血清脂联素和内脂素水平与糖尿病肾病的相关性

发布时间：2018-07-26 10:45

【摘要】：目的评估2型糖尿病患者血清脂联素和血清内脂素水平与糖尿病肾病间的相关性。方法 2型糖尿病患者96例,根据尿蛋白及尿微量白蛋白的水平分为单纯糖尿病组(36例)和糖尿病肾病组(60例)。同时,以同期行常规体检的健康者30例为对照组。分析和比较各组受试者的血清脂联素和内脂素水平,筛选可用于预测2型糖尿病肾病发生的血清标记物。结果糖尿病患者的血清脂联素均明显低于对照组,血清内脂素水平均明显高于对照组(P0.05)。而且,糖尿病肾病组血清脂联素和内脂素水平均明显高于单纯糖尿病组(P0.05)。进一步多因素Logistic回归分析显示,血清内脂素是2型糖尿病患者发生糖尿病肾病的独立危险因素。结论血清脂联素水平降低和血清内脂素水平升高与2型糖尿病肾病的发生密切相关,血清内脂素水平升高可能预示2型糖尿病患者糖尿病肾病的发生或加重。
[Abstract]:Objective to evaluate the relationship between serum adiponectin and serum adiponectin levels and diabetic nephropathy in patients with type 2 diabetes. Methods 96 patients with type 2 diabetes were divided into simple diabetes group (36 cases) and diabetic nephropathy group (60 cases). At the same time, 30 healthy subjects who underwent routine physical examination at the same time were taken as the control group. Serum adiponectin and endogenous adiponectin levels were analyzed and compared to screen serum markers for predicting the occurrence of type 2 diabetic nephropathy. Results Serum adiponectin levels and serum adiponectin levels in diabetic patients were significantly lower than those in control group (P0.05). Moreover, the levels of adiponectin and endogenous adiponectin in diabetic nephropathy group were significantly higher than those in simple diabetic group (P0.05). Further multivariate Logistic regression analysis showed that serum lipopolysaccharide was an independent risk factor for diabetic nephropathy in type 2 diabetic patients. Conclusion the decrease of serum adiponectin level and the increase of serum adiponectin level are closely related to the occurrence of type 2 diabetic nephropathy. The increase of serum adiponectin level may indicate the occurrence or aggravation of diabetic nephropathy in type 2 diabetic patients.
【作者单位】：常州市第七人民医院内分泌代谢科;
【分类号】：R587.1

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