妇科恶性肿瘤术后骨质疏松症的临床观察

发布时间：2018-08-03 08:54

【摘要】：目的观察妇科恶性肿瘤术后骨密度(bone mineral density,BMD)的变化情况,为术后骨质疏松症的防治提供理论基础。方法以2013年10月-2015年11月我院收治的26例妇科恶性肿瘤患者为试验组,其中宫颈癌患者14例,子宫内膜癌患者4例,卵巢癌患者8例,年龄38~53岁,平均年龄(46.01±4.13)岁,患者术中均行子宫全切术和双侧附件切除术;以同期在我院进行体检的同年龄段30例健康女性作为对照组,采用双能X线骨密度仪测定受试者腰正位(L3-4)及左髋部(股骨颈)的BMD情况;同时测定其血清激素水平情况。结果与对照组相比,妇科恶性肿瘤术后腰椎BMD明显下降(P0.05),有统计学意义;血清雌二醇(estradiol,E2)值与对照组比较有所下降(P0.05),促卵泡刺激素(follicle-stimulating hormone,FSH)与对照组比较有明显上升(P0.05),均有统计学意义。结论妇科恶性肿瘤术后因雌激素急剧下降可加速骨质丢失,术后尽早防治骨质疏松对提高患者生活质量有很大的作用。
[Abstract]:Objective to observe the changes of bone mineral density (bone mineral) after operation of gynecologic malignant tumors, and to provide a theoretical basis for the prevention and treatment of osteoporosis. Methods from October 2013 to November 2015, 26 patients with gynecological malignant tumors were treated in our hospital as experimental group. 14 patients with cervical cancer, 4 patients with endometrial carcinoma and 8 patients with ovarian cancer were enrolled in the study group. The average age was (46.01 卤4.13) years. All patients underwent total hysterectomy and bilateral appendectomy during operation, 30 healthy women of the same age who were examined in our hospital at the same time were taken as the control group. Dual energy X-ray absorptiometry was used to measure the BMD of L3-4 and left hip (femoral neck), and the serum hormone level was also measured. Results compared with the control group, the BMD of lumbar vertebrae decreased significantly after operation of gynecologic malignant tumor (P0.05). The serum estradiolol E 2 level was lower than that of the control group (P0.05), and the serum follicle-stimulating hormone level was significantly higher than that of the control group (P0.05). Conclusion the rapid decline of estrogen can accelerate bone loss after operation for gynecologic malignant tumors. Early prevention and treatment of osteoporosis can improve the quality of life of patients with gynecological malignancy.
【作者单位】：内蒙古医科大学第二附属医院;
【分类号】：R737.3;R580

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