锦州地区老年人骨质疏松症影响因素的病例对照研究

发布时间：2018-08-05 20:14

【摘要】：目的本研究旨在探讨锦州地区老年人骨质疏松症患病的影响因素,为骨质疏松症的防治提供依据及策略。方法本研究采用非匹配病例对照研究,将2015年11月-2016年5月期间,锦州医科大学附属第一医院体检中心行骨密度检测且年龄≥60岁的锦州地区老年人作为研究对象。病例为行骨密度检测后诊断为骨质疏松的195例老年人,对照为与病例同期行该检测后诊断为骨量减少及骨量正常的242例老年人。对研究对象进行自行设计问卷调查,数据采用t检验、χ~2检验及秩和检验进行单因素分析,采用非条件logistic回归进行多因素分析,筛选老年人骨质疏松症患病的影响因素。结果1、单因素分析显示:病例组与对照组在年龄(t=-5.79,P=0.000)、体重指数(t=3.41,P=0.001)、性别(χ~2=8.78,P=0.003)、民族(χ~2=5.96,P=0.015)、吸烟(χ~2=6.39,P=0.012)、饮酒(χ~2=10.08,P=0.002)、参加体育锻炼(χ~2=9.59,P=0.002)、摄入谷氨酸钠(χ~2=11.41,P=0.001)、摄入乳制品(χ~2=12.52,P=0.000)、补充钙剂(χ~2=7.76,P=0.005)、补充维生素D(χ~2=6.81,P=0.009)、文化程度(Z=-2.50,P=0.012)、饮酒频率(Z=-2.39,P=0.017)、每次锻炼时间(Z=-3.88,P=0.000)、补充钙剂频率(Z=-2.16,P=0.031)、坚持摄入乳制品时间(Z=-2.11,P=0.035)及摄入海产品频率(Z=-2.51,P=0.012)上差异具有统计学意义。2、多因素分析显示:年龄(OR=1.094,95%CI=1.052~1.137)、性别(OR=3.069,95%CI=1.800~5.234)、吸烟(OR=1.729,95%CI=1.009~2.964)、饮酒(OR=2.044,95%CI=1.067~3.917)及摄入谷氨酸钠(OR=1.676,95%CI=1.040~2.701)是老年人骨质疏松症发生的危险因素;每次锻炼时间(OR=0.809,95%CI=0.659~0.995)、补充维生素D(OR=0.524,95%CI=0.294~0.935)及海产品摄入频率(OR=0.779,95%CI=0.644~0.942)是老年人骨质疏松症发生的保护因素。结论年龄增长、女性、吸烟、饮酒及摄入谷氨酸钠是影响锦州地区老年人骨质疏松症发生的重要危险因素,而适当参加体育锻炼、适量补充维生素D及摄入海产品有助于防治老年人骨质疏松症的发生。
[Abstract]:Objective to explore the influencing factors of osteoporosis in the elderly in Jinzhou, and to provide a basis and strategy for the prevention and treatment of osteoporosis. Methods this study adopted a non matched case control study to examine the bone mineral density of the medical center of the first hospital of Jinzhou Medical University in November 2015 during the period of May -2016, and the age was more than 60. The elderly in Jinzhou, Jinzhou, were used as the research object. The cases were diagnosed as osteoporosis after bone density detection. The control was 242 elderly patients who were diagnosed as bone mass reduction and normal bone mass. The subjects were investigated by self-designed questionnaire with t test, X ~2 test and rank sum test. A single factor analysis was carried out with non conditional logistic regression to analyze the factors affecting the prevalence of osteoporosis in the elderly. Results 1, single factor analysis showed that the case group and the control group were in the age (t=-5.79, P=0.000), body mass index (t=3.41, P=0.001), sex (chi ~2=8.78, P=0.003), nationality (chi ~2=5.96, P=0.015), smoking (x ~2=) (x ~2=). 6.39, P=0.012, drink (x ~2=10.08, P=0.002), take part in physical exercise (x ~2=9.59, P=0.002), intake of sodium glutamate (chi ~2=11.41, P=0.001), dairy products (chi ~2=12.52, P=0.000), supplemental calcium (chi, ~2=7.76, P=0.005), supplemental vitamin D, drinking frequency, drinking frequency, every exercise. (Z=-3.88, P=0.000), supplemental calcium frequency (Z=-2.16, P=0.031), adhere to the intake of dairy products time (Z=-2.11, P=0.035) and the intake of seafood frequency (Z=-2.51, P=0.012) with statistical significance in.2. Multifactor analysis showed that age (OR=1.094,95%CI= 1.052~1.137), sex (OR=3.069,95%CI=1.800~5.234), smoking. 4), drinking (OR=2.044,95%CI=1.067~3.917) and sodium glutamate (OR=1.676,95%CI=1.040~2.701) are the risk factors for the onset of osteoporosis in the elderly; each exercise time (OR=0.809,95%CI=0.659~0.995), vitamin D (OR=0.524,95%CI=0.294~0.935) and the frequency of seafood intake (OR=0.779,95%CI=0.644~0.942) are senile osteoporosis It is concluded that age increase, female, smoking, drinking and sodium glutamate are important risk factors affecting the occurrence of osteoporosis in the elderly in Jinzhou, and proper participation in physical exercise, supplementation of vitamin D and the intake of seafood will help prevent the occurrence of osteoporosis in the elderly.
【学位授予单位】：锦州医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R580

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