甘油三酯葡萄糖乘积指数与心血管疾病危险因素聚集关系的研究

发布时间：2018-08-07 18:59

【摘要】：目的探讨成年人甘油三酯葡萄糖乘积(triglyceride-glucose index,TyG)指数与心血管疾病危险因素聚集的关系。方法采用随机抽样的方法,调查安徽省蚌埠市龙子湖区居民,共1 777名,调查内容主要包括问卷调查,身体指标测量和实验室检查。将TyG指数按四分位数分组,使用Logistic多因素回归分析TyG指数与心血管疾病危险因素聚集的关系。通过受试者工作特征(receiver operator characteristic curve,ROC)曲线分析,计算TyG指数判断心血管疾病危险因素聚集的临界值及作用大小,并与其余指标进行比较。结果调查人群男性748人(42.09%),女性1 029人(57.91%)。平均年龄为(60.82±11.24)岁。Spearman相关分析表明TyG指数与心血管疾病危险因素均存在相关性(均有P0.001)。Logistic多因素分析显示,TyG指数是心血管疾病危险因素聚集的危险因素(OR=2.930,95%CI:2.625~3.272)。TyG指数为8.78时,判断心血管疾病危险因素聚集的约登指数最大。其ROC曲线下面积与空腹血糖、甘油三酯、身高体重指数(body mass index,BMI)的相比差异均有统计学意义(均有P0.05),而与腰围身高比(waist-to-height ratio,WHtR)的差异无统计学意义(Z=0.117,P=0.907)。结论TyG指数与心血管危险因素聚集密切相关,可做为识别心血管疾病危险因素聚集的简单工具。
[Abstract]:Objective to investigate the relationship between the triglyceride-glucose index and the risk factors of cardiovascular disease in adults. Methods A total of 1 777 residents in Longzihu District, Bengbu City, Anhui Province were investigated by random sampling. The contents of the survey included questionnaire survey, physical index measurement and laboratory examination. TyG index was divided into four quartiles, and Logistic multivariate regression analysis was used to analyze the relationship between TyG index and cardiovascular disease risk factor aggregation. By analyzing the operating characteristics of (receiver operator characteristic, the critical value and the effect of TyG index for judging the risk factors of cardiovascular disease were calculated and compared with the other indexes. Results 748 males (42.09%) and 1 029 females (57.91%) were investigated. The average age was (60.82 卤11.24) years old. Spearman correlation analysis showed that there was correlation between TyG index and cardiovascular disease risk factors (P0.001). Logistic multivariate analysis showed that TyG index was the risk factor of cardiovascular disease risk factor aggregation (ORT 2.930 95 CI: 2.6253.272) .TyG index was 8.78. The Jorden index was the largest in judging the concentration of cardiovascular disease risk factors. The area under the ROC curve was significantly different from that of fasting blood glucose, triglyceride and body mass index (body mass) (P0.05), but had no significant difference with waist-to-height ratio (0.907). Conclusion TyG index is closely related to the concentration of cardiovascular risk factors and can be used as a simple tool to identify the clustering of cardiovascular disease risk factors.
【作者单位】：蚌埠医学院预防医学系;
【基金】：国家自然科学基金(81373100)
【分类号】：R587.1

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