男性高尿酸血症患者成纤维细胞因子21与血尿酸和胰岛素抵抗的关系
发布时间：2018-08-08 14:01
【摘要】：目的探讨男性高尿酸血症(HUA)患者中成纤维细胞因子21(FGF21)水平与血尿酸(SUA)和IR的关系。方法在体检人群中选择男性高尿酸血症患者(HUA组)和健康者(NC组)各85名,HUA组以BMI水平分为HUA-高BMI亚组(n=41)及HUA-正常BMI亚组(n=44),分别检测FGF21、Hb A_1 c、BP、血脂、HOMA-IR等参数。结果 HUA组FGF21高于NC组[(1.99±0.96)vs(1.73±0.50)ng/ml,P0.05];HUA-高BMI亚组FGF21水平高于HUA-正常BMI亚组[(2.04±3.61)vs(1.84±2.15)ng/ml,P0.05];FGF21水平与BMI、WHR、TG、ln(HOMA-IR)、FIns、SUA呈正相关(r=0.456、0.355、0.231、0.257、0.220、0.222,P0.05或P0.01);多元线性逐步回归分析显示,WHR、SUA、ln(HOMA-IR)、TG是血清FGF21独立影响因素(P0.05)。结论 FGF21在男性HUA患者中升高,且与SUA、1n(HOMA-IR)、BMI、WHR及脂代谢相关,其可能参与男性HUA患者的病理生理过程。
[Abstract]:Objective to investigate the relationship between the level of fibroblast factor 21 (FGF21) and serum uric acid (SUA) and IR in male patients with hyperuricemia (HUA). Methods 85 male patients with hyperuricemia (HUA group) and 85 healthy controls (NC group) were divided into two groups according to their BMI level: HUA-high BMI subgroup (nong41) and HUA-normal BMI subgroup (nb44). 缁撴灉 HUA缁凢GF21楂樹簬NC缁刐(1.99卤0.96)vs(1.73卤0.50)ng/ml,P0.05];HUA-楂楤MI浜氱粍FGF21姘村钩楂樹簬HUA-姝ｅ父BMI浜氱粍[(2.04卤3.61)vs(1.84卤2.15)ng/ml,P0.05];FGF21姘村钩涓嶣MI,WHR,TG,ln(HOMA-IR),FIns,SUA鍛堟鐩稿叧(r=0.456,0.355,0.231,0.257,0.220,0.222,P0.05鎴朠0.01);澶氬厓绾挎，
本文编号：2172012
[Abstract]:Objective to investigate the relationship between the level of fibroblast factor 21 (FGF21) and serum uric acid (SUA) and IR in male patients with hyperuricemia (HUA). Methods 85 male patients with hyperuricemia (HUA group) and 85 healthy controls (NC group) were divided into two groups according to their BMI level: HUA-high BMI subgroup (nong41) and HUA-normal BMI subgroup (nb44). 缁撴灉 HUA缁凢GF21楂樹簬NC缁刐(1.99卤0.96)vs(1.73卤0.50)ng/ml,P0.05];HUA-楂楤MI浜氱粍FGF21姘村钩楂樹簬HUA-姝ｅ父BMI浜氱粍[(2.04卤3.61)vs(1.84卤2.15)ng/ml,P0.05];FGF21姘村钩涓嶣MI,WHR,TG,ln(HOMA-IR),FIns,SUA鍛堟鐩稿叧(r=0.456,0.355,0.231,0.257,0.220,0.222,P0.05鎴朠0.01);澶氬厓绾挎，
本文编号：2172012
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