乳酸菌对高脂血症小鼠血脂和肠道菌的影响
发布时间：2018-08-09 12:00
【摘要】：目的:研究功能乳酸菌制剂的降血脂作用及对肠道菌的影响。方法:建立小白鼠高脂血症动物模型;模型小鼠30只,随机分为:生理盐水组、复合乳酸菌组和辛伐他汀组,每组10只。采取灌胃处理,分别灌服生理盐水、复合乳酸菌制剂(等比例混合的植物乳杆菌、嗜酸乳杆菌和干酪乳杆菌)和降血脂药物辛伐他汀。结果:与生理盐水比较,乳酸菌和辛伐他汀药物处理显著降低了小鼠血清胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(HDL-C)含量(P0.05);乳酸菌处理和药物处理间TC、TG和HDL-C无显著差异。与降血脂药物相比,乳酸菌处理显著增加小鼠粪便乳酸菌数量(P0.05),降低了大肠杆菌(P0.05)和肠球菌数量(P0.01)。结论:乳酸菌制剂具有降低血脂、增加肠道有益菌数量、降低肠道有害菌数量的作用。
[Abstract]:Objective: to study the effect of functional lactic acid bacteria preparation on blood lipids and intestinal bacteria. Methods: a model of hyperlipidemia in mice was established, and 30 mice were randomly divided into normal saline group, compound lactic acid bacteria group and simvastatin group with 10 rats in each group. The rats were treated by intragastric administration of normal saline, compound lactic acid bacteria (equal proportion of Lactobacillus plantarum, Lactobacillus acidophilus and Lactobacillus casei) and simvastatin, a hypolipidemic drug. Results: compared with normal saline, lactic acid bacteria and simvastatin significantly decreased the levels of serum cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (HDL-C) in mice (P0.05), but there was no significant difference between lactic acid bacteria treatment and drug treatment in TCTG and HDL-C. Compared with antilipidemic drugs, lactic acid bacteria treatment significantly increased the number of lactic acid bacteria in feces of mice (P0.05), decreased the number of Escherichia coli (P0.05) and enterococci (P0.01). Conclusion: lactic acid bacteria can reduce blood lipid, increase the number of intestinal beneficial bacteria and decrease the number of harmful bacteria.
【作者单位】： 山东临沂罗庄中心医院检验科;山东省农业科学院生物技术研究中心;
【基金】：国家科技支撑计划(2012BAK17B00) 山东省科技发展计划(2012GGC02026)
【分类号】：R589.2
，
本文编号：2174009
[Abstract]:Objective: to study the effect of functional lactic acid bacteria preparation on blood lipids and intestinal bacteria. Methods: a model of hyperlipidemia in mice was established, and 30 mice were randomly divided into normal saline group, compound lactic acid bacteria group and simvastatin group with 10 rats in each group. The rats were treated by intragastric administration of normal saline, compound lactic acid bacteria (equal proportion of Lactobacillus plantarum, Lactobacillus acidophilus and Lactobacillus casei) and simvastatin, a hypolipidemic drug. Results: compared with normal saline, lactic acid bacteria and simvastatin significantly decreased the levels of serum cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (HDL-C) in mice (P0.05), but there was no significant difference between lactic acid bacteria treatment and drug treatment in TCTG and HDL-C. Compared with antilipidemic drugs, lactic acid bacteria treatment significantly increased the number of lactic acid bacteria in feces of mice (P0.05), decreased the number of Escherichia coli (P0.05) and enterococci (P0.01). Conclusion: lactic acid bacteria can reduce blood lipid, increase the number of intestinal beneficial bacteria and decrease the number of harmful bacteria.
【作者单位】： 山东临沂罗庄中心医院检验科;山东省农业科学院生物技术研究中心;
【基金】：国家科技支撑计划(2012BAK17B00) 山东省科技发展计划(2012GGC02026)
【分类号】：R589.2
，
本文编号：2174009
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