多发性硬化血清麻疹、风疹和水痘-带状疱疹病毒IgG抗体水平及临床意义
发布时间：2018-08-09 20:06
【摘要】：目的通过检测多发性硬化(Multiple sclerosis,MS)患者血清中麻疹病毒、风疹病毒和水痘-带状疱疹病毒的免疫球蛋白G(Immunoglobulin G,IgG)抗体浓度,并进行扩展残疾状态量表(Expanded disability status scale,EDSS)评分,探讨上述病毒在MS发病中的临床意义及其与临床神经功能缺失的相关性。方法收集2013年9月-2015年2月郑州大学第一附属医院神经内科收治的50例MS患者急性期(复发期)的血清标本,其中临床孤立综合征(CIS亚组)22例,复发-缓解型MS(RRMS亚组)28例,对照组收集同一时期我院体检结果正常的37例健康志愿者的血清标本。采用双抗体夹心酶联免疫吸附方法(Enzyme linked immunosorbent assay,ELISA)测定并比较血清中3种病毒IgG抗体的浓度,分析血清中各病毒抗体水平与EDSS评分的相关性。结果 (1)MS病例组麻疹病毒、风疹病毒、水痘-带状疱疹病毒IgG抗体的血清浓度高于对照组,差异具有统计学意义(P0.05);(2)CIS亚组患者血清中麻疹病毒、风疹病毒、水痘-带状疱疹病毒IgG抗体水平低于RRMS亚组,EDSS评分亦低于RRMS亚组,差异均具有统计学意义(P0.05);(3)MS病例组血清中麻疹病毒、风疹病毒、水痘-带状疱疹病毒IgG抗体与EDSS评分无相关性(P0.05)。结论 MS患者血清中的麻疹病毒、风疹病毒和水痘-带状疱疹病毒可能不仅与MS的发病相关,而且与疾病的复发有关。
[Abstract]:Objective to detect the antibody concentration of measles virus, rubella virus and varicella zoster virus in serum of patients with multiple sclerosis (Multiple sclerosis MS), and to evaluate the (Expanded disability status scale (EDSS). To investigate the clinical significance of the above-mentioned virus in the pathogenesis of MS and its correlation with clinical nerve function loss. Methods Serum samples were collected from 50 patients with MS in the Department of Neurology, first affiliated Hospital of Zhengzhou University from September 2013 to February 2015. The clinical isolated syndrome (CIS subgroup) was 22 cases, and the relapse-remission MS (RRMS subgroup (28 cases). The control group collected 37 healthy volunteers with normal physical examination results in the same period. A double antibody sandwich enzyme linked immunosorbent assay (Enzyme linked immunosorbent assayer Elisa) was used to detect and compare the concentration of three virus IgG antibodies in serum and to analyze the correlation between the serum antibody levels and the EDSS score. Results (1) the serum concentrations of measles virus, rubella virus and varicella zoster virus IgG antibody in MS group were higher than those in control group (P0.05); (2). The serum levels of measles virus and rubella virus in CIS subgroup were significantly higher than those in control group. The IgG antibody level of varicella-zoster virus was lower than that of RRMS subgroup and RRMS subgroup, the difference was statistically significant (P0.05); (3). There was no correlation between EDSS score and measles virus, rubella virus, varicella zoster virus IgG antibody in MS group (P0.05). Conclusion measles virus, rubella virus and varicella zoster virus in serum of MS patients may be related not only to the pathogenesis of MS, but also to the recurrence of the disease.
【作者单位】： 郑州大学第一附属医院神经内科;郑州市中心医院神经内科;
【基金】：河南省科技厅普通攻关资助项目(No.142102310057)
【分类号】：R744.51
，
本文编号：2175172
[Abstract]:Objective to detect the antibody concentration of measles virus, rubella virus and varicella zoster virus in serum of patients with multiple sclerosis (Multiple sclerosis MS), and to evaluate the (Expanded disability status scale (EDSS). To investigate the clinical significance of the above-mentioned virus in the pathogenesis of MS and its correlation with clinical nerve function loss. Methods Serum samples were collected from 50 patients with MS in the Department of Neurology, first affiliated Hospital of Zhengzhou University from September 2013 to February 2015. The clinical isolated syndrome (CIS subgroup) was 22 cases, and the relapse-remission MS (RRMS subgroup (28 cases). The control group collected 37 healthy volunteers with normal physical examination results in the same period. A double antibody sandwich enzyme linked immunosorbent assay (Enzyme linked immunosorbent assayer Elisa) was used to detect and compare the concentration of three virus IgG antibodies in serum and to analyze the correlation between the serum antibody levels and the EDSS score. Results (1) the serum concentrations of measles virus, rubella virus and varicella zoster virus IgG antibody in MS group were higher than those in control group (P0.05); (2). The serum levels of measles virus and rubella virus in CIS subgroup were significantly higher than those in control group. The IgG antibody level of varicella-zoster virus was lower than that of RRMS subgroup and RRMS subgroup, the difference was statistically significant (P0.05); (3). There was no correlation between EDSS score and measles virus, rubella virus, varicella zoster virus IgG antibody in MS group (P0.05). Conclusion measles virus, rubella virus and varicella zoster virus in serum of MS patients may be related not only to the pathogenesis of MS, but also to the recurrence of the disease.
【作者单位】： 郑州大学第一附属医院神经内科;郑州市中心医院神经内科;
【基金】：河南省科技厅普通攻关资助项目(No.142102310057)
【分类号】：R744.51
，
本文编号：2175172
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