初诊2型糖尿病患者餐后骨转换标志物的动态变化

发布时间：2018-08-10 20:54

【摘要】：目的探讨初诊2型糖尿病(T2DM)男性患者馒头餐后血清骨转换标志物的动态变化。方法随机选取46例男性初诊T2DM患者(T2DM组)及40例年龄相匹配的体检健康男性(对照组)作为研究对象,所有受试者空腹采静脉血后进食100 g馒头,分别测定空腹及餐后30、60、120及180 min血清1型原胶原N-端前肽(P1NP)及1型胶原交联C-末端肽(β-CTX)等指标,并进行统计学分析。结果空腹状态下,T2DM组的血清P1NP及β-CTX水平均显著低于对照组[P1NP:(40.6±12.9)ng/m L vs(54.2±14.8)ng/m L。β-CTX:(318.6±89.4)pg/m L vs(396.3±105.7)pg/m L。均P0.05]。与空腹状态下相比,2组餐后各时间点的血清P1NP水平均无显著变化,而血清β-CTX水平随着时间延长显著降低,且均在120 min降至最低,随后略有升高。餐后120 min,T2DM组的血清β-CTX降低率显著低于对照组(34.6%vs 45.2%,P=0.006)。结论初诊T2DM患者的血清骨转换标志物水平显著低于健康人群,并且进食抑制骨吸收的能力也显著降低,这可能是T2DM患者骨折风险增加的原因之一。
[Abstract]:Objective to investigate the dynamic changes of serum bone turnover markers in male patients with newly diagnosed type 2 diabetes mellitus (T2DM) after meal. Methods Forty-six newly diagnosed T2DM patients (T2DM group) and 40 age-matched healthy men (control group) were randomly selected as study subjects. The serum levels of procollagen type 1 N-terminal prepeptide (P1NP) and cross-linked C-terminal peptide (尾 -CTX) of procollagen type 1 were measured and analyzed statistically. Results the serum levels of P1NP and 尾 -CTX in the T2DM group were significantly lower than those in the control group [P1NP: (40.6 卤12.9) ng/m L vs (: 54.2 卤14.8] ng/m L. 尾 -CTX: (318.6 卤89.4) pg/m L vs (396.3 卤105.7 pg/m L. P 0.05]. Compared with the fasting state, the serum P1NP levels of the two groups did not change significantly, but the serum 尾 -CTX levels decreased significantly with time, reached the lowest level at 120 min, and then increased slightly. The decrease rate of serum 尾 -CTX in 120min T2DM group was significantly lower than that in control group (34.6%vs 45.2). Conclusion the level of serum bone turnover markers in newly diagnosed T2DM patients is significantly lower than that in healthy people, and the ability of eating to inhibit bone resorption is also significantly reduced, which may be one of the reasons for the increase of fracture risk in patients with T2DM.
【作者单位】：苏州大学附属第三医院内分泌科;上海交通大学附属第六人民医院内分泌代谢科;
【基金】：常州市科技局项目(CJ20159019)~~
【分类号】：R587.1

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