胱抑素C在痛风性关节炎患者中的水平及临床意义

发布时间：2018-08-13 17:55

【摘要】：目的:探讨Cys-C在痛风性关节炎患者中的水平及临床意义。方法:纳入152例痛风性关节炎患者作为痛风组,入选57例年龄、性别相匹配的健康体检者作为对照组,收集两组人员包括Cys-C在内的生化指标及其它临床数据,分别依据不同年龄及病程进行分组,并进行组间比较及相关性分析,比较包括Cys-C在内的反应肾功能受损的指标在早期痛风肾病中的价值。分析LVEF与Cys-C之间的关系。数据采用SPSS18.0软件进行统计学分析。结果:1.痛风组Cys-C水平(1.63±0.70)mg/l明显高于健康对照组(0.83±0.12)mg/l,差异有统计学意义(P0.01);2.依据年龄将痛风性关节炎患者分为三个亚组(青年组(45岁);中年组(45-59岁);老年组(≥60岁)),三组间Cys-C水平分别为:青年组(1.15±0.26)mg/l,中年组(1.68±0.54)mg/l,老年组(2.04±0.83)mg/l,随着年龄段的升高,Cys-C的水平也不断升高,组间进行SNK-q检验,各组间差异均具有统计学意义(P0.05);痛风组青年组、中年组、老年组三组间Cys-C水平(1.15±0.26,1.68±0.54,2.04±0.83)mg/l均较对照组高(0.85±0.14,0.82±0.13,0.81±0.08)mg/l,差异均具有显著统计学意义(P0.01)。3.依据痛风性关节炎患者的病程分为两组(病程≤5年组;病程5年组):病程5年组Cys-C水平(1.83±0.76)mg/l明显高于病程≤5年组(1.45±0.58)mg/l,差异有显著统计学意义(P0.01);4.以eGFR作为判断肾功能受损的指标,eGFRcr判断肾功能损害的阳性率为19.74%,低于eGFRcys(68.42%)及eGFRcr-cys(45.39%);5.LVEF异常组Cys-C水平明显高于LVEF正常组(2.64±0.67 vs 1.32±0.32)mg/l,差异具有显著统计学意义(P0.01);6.Cys-C水平与BUN、Cr、年龄、ESR等临床指标均具有相关性,Cys-C水平与BUA、CRP、TC、TG、HDL、LDL无相关性。结论:1.eGFRcys及eGFRcr-cys较eGFRcr更适合作为评估早期肾功能损伤发生的指标;2.Cys-C是除BUN、Cr之外另一个早期评价痛风性关节炎患者肾功能损害的指标;3.痛风性关节炎患者Cys-C水平升高可能提示合并心功能不全的风险升高。
[Abstract]:Objective: to investigate the level and clinical significance of Cys-C in patients with gouty arthritis. Methods: 152 patients with gouty arthritis were selected as gout group and 57 healthy persons matched with age and sex as control group. Biochemical indexes including Cys-C and other clinical data were collected from both groups. According to the age and course of disease, the patients were divided into groups and compared with each other, and the correlation analysis was carried out to compare the value of the indexes of reactive renal function including Cys-C in early gout nephropathy. The relationship between LVEF and Cys-C was analyzed. The data were analyzed by SPSS18.0 software. The result is 1: 1. The level of Cys-C in gout group (1.63 卤0.70) mg/l was significantly higher than that in healthy control group (0.83 卤0.12) mg / L, the difference was statistically significant (P0.01). According to age, gouty arthritis patients were divided into three subgroups (youth group (45 years), middle age group (45-59 years old), aged group (鈮，

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