柳氮磺吡啶治疗成人斯蒂尔病的超说明书用药循证评价

发布时间：2018-08-15 13:58

【摘要】：目的:系统评价柳氮磺吡啶治疗成人斯蒂尔病超说明书用药的合理性。方法:查询国内外网站柳氮磺吡啶的最新版药品说明书、权威指南和诊疗规范,收集柳氮磺吡啶的全部适应证。计算机检索Pub Med、EMbase、Cochrane、Clinicaltrials、CBM、CNKI、VIP和万方数据库,检索时限为从建库至2015年10月,收集柳氮磺吡啶治疗成人斯蒂尔病超说明书用药研究文献,对该药治疗成人斯蒂尔病的有效性和安全性进行系统性评价。结果:国内外最新版的说明书均未找到柳氮磺吡啶治疗成人斯蒂尔病的适应证,仅有中华风湿病学杂志刊出的《成人斯蒂尔病诊断及治疗指南》(2010年)和中华医学会编著的《临床诊疗指南-风湿病分册》(2005年)提及柳氮磺吡啶可以用于治疗成人斯蒂尔病。查询所有数据库,尚未找到柳氮磺吡啶治疗成人斯蒂尔病的随机、对照、多中心临床试验,仅有少数的病例报道、回顾性分析、观察性研究等文献报道了该药的有效性和安全性。结论:目前有关柳氮磺吡啶治疗成人斯蒂尔病的推荐证据等级较低,尚需大样本的随机对照试验证实本药的有效性,且该药在治疗过程中存在潜在的严重安全性问题,因此建议成人斯蒂尔病患者应避免使用柳氮磺吡啶。
[Abstract]:Objective: to evaluate the rationality of superscript administration of sulfasalopyridine in the treatment of adult Steele disease. Methods: the latest drug instruction, authoritative guide and diagnosis and treatment standard of sulfasalopyridine at home and abroad were consulted, and all indications of sulfasalopyridine were collected. To search the database of Pub Medbase Cochranesius Clinicaltrialsof Pub and Wanfang by computer, the search time was from the establishment of the database to October 2015, and the literature on the drug use of sulfasalopyridine in the treatment of adult Steele's disease was collected. The efficacy and safety of the drug in the treatment of adult Steele's disease were systematically evaluated. Results: no indication of salicylazosulfopyridine for treatment of adult Steele's disease was found in the latest edition of the instruction book at home and abroad. Only the guidelines for the diagnosis and treatment of adult Steele's disease (2010) published in the Chinese Journal of Rheumatology and the Chinese Medical Association's guidelines for Clinical diagnosis and treatment of Rheumatology (2005) mention that sulfasalopyridine can be used in the treatment of adult Steele's disease. All databases have not yet been found in random, controlled, multicenter clinical trials of sulfasalopyridine for adult Steele's disease, with only a few reported cases, retrospective analysis, The efficacy and safety of the drug were reported in the literature. Conclusion: at present, the recommended evidence of sulfasalopyridine in the treatment of adult Steele's disease is relatively low, and a large sample randomized controlled trial is needed to confirm the efficacy of the drug, and there are potentially serious safety problems during the treatment. Therefore, it is recommended that adult patients with Steele's disease should avoid the use of sulfasalopyridine.
【作者单位】：第三军医大学第一附属医院药学部;浙江医科大学第一附属医院药剂科;
【基金】：国家卫生计生委医疗管理服务指导中心项目
【分类号】：R593.2

【相似文献】