2型糖尿病患者白蛋白尿水平与血清总胆汁酸浓度的相关性

发布时间：2018-08-16 07:42

【摘要】：目的研究2型糖尿病患者微量白蛋白尿水平与血清总胆汁酸(TBA)浓度的关系。方法选取2型糖尿病患者186例,将其分为正常白蛋白尿组(A),微量白蛋白尿组(B),大量白蛋白尿组(C)。观察3个分组中2型糖尿病患者微量白蛋白尿水平与TBA浓度的关系。并探究2型糖尿病患者微量白蛋白尿水平与年龄、体质指数(BMI)、空腹葡萄糖(FPG)、糖化血红蛋白(HbA_(1C))、血脂指标、甲状腺功能相关指标等方面的差异。结果 3组患者TBA的浓度有显著差异(P0.05)。3组患者中,白蛋白尿水平与高密度脂蛋白胆固醇(HDL-C)、三碘甲状腺原氨酸(TT3)水平有统计学差异(P0.05)。2型糖尿病患者白蛋白尿水平与TBA有相关性。结论在2型糖尿病患者中,随着白蛋白尿的增加,TBA浓度逐渐下降。
[Abstract]:Objective to study the relationship between microalbuminuria and serum total bile acid (TBA) concentration in type 2 diabetes mellitus. Methods 186 patients with type 2 diabetes mellitus were divided into normal albuminuria group, (A), microalbuminuria group, (B), macroalbuminuria group (C). To observe the relationship between microalbuminuria and TBA concentration in 3 groups of type 2 diabetic patients. The differences of microalbuminuria level and age, fasting glucose (FPG), glycosylated hemoglobin (HbA1C),) and thyroid function in type 2 diabetic patients were investigated. Results there was significant difference in the concentration of TBA among the three groups (P0.05). In the three groups, the level of albuminuria was significantly different from that of high density lipoprotein cholesterol (HDL-C) and triiodothyronine (TT3) (P0.05). There was a correlation between the level of albuminuria and TBA in type 2 diabetes mellitus (P0.05). Conclusion in type 2 diabetes mellitus, the concentration of TBA decreases with the increase of albuminuria.
【作者单位】：河北医科大学研究生学院;河北省人民医院内分泌科;
【分类号】：R587.1

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