基于经济博弈的双激素血糖控制

发布时间：2018-08-23 07:58

【摘要】：胰岛素泵疗法是一种通过皮下持续输注胰岛素来控制糖尿病人血糖的设备。多项研究证明,对于1型和部分2型糖尿病人而言,胰岛素泵治疗方法可以很好的控制血糖,使用起来也方便,对于各个年龄段的人群都适用,因此胰岛素泵的使用正在增加。当前,胰岛素泵主要采用单激素策略(只输注胰岛素),可是单激素控制方法无法对病人出现的低血糖状况进行及时的补救处理,而人体即使出现短时间的低血糖就可能造成极大的危险,甚至对生命构成危险,因此使用胰高血糖素来解决这个问题是很好的选择。很多临床试验表明双激素疗法(输注胰岛素和胰高血糖素)是最有希望控制血糖的办法,它可以更精确的模拟人体胰岛分泌两种激素的生理方式。针对上述问题,本文研究的双激素控制策略和方法,旨在进一步降低低血糖出现的几率,从而更好的减少甚至避免低血糖所带来的严重危害。本文采用MPC和博弈论的思想对双激素控制中的两个子系统设计了预测控制器,并设计了代价函数和切换规则,并对此方案进行性了仿真实验,证明了该方法的有效性。同时将该切换控制方法同传统的单激素控制和双激素控制方法进行了实验对比并进行了鲁棒性测试,证明了该方法的优越性。研究的最终目的是利用模型预测控制(MPC)和博弈论,设计出一个合理的、有效的控制方法来协调两种激素的注射,并使其达到经济利益最大化。本文基于MPC和博弈论的“人工胰脏”双激素控制方案,希望可以得到新的有关糖尿病治疗的方法和思路。
[Abstract]:Insulin pump therapy is a device for controlling blood sugar in diabetics by continuous subcutaneous insulin infusion. A number of studies have shown that for type 1 and part of type 2 diabetics, insulin pump therapy can control blood sugar very well and is convenient to use, and is suitable for people of all ages, so the use of insulin pump is increasing. At present, the insulin pump mainly adopts the single hormone strategy (only infusing insulin), but the single hormone control method can not carry on the prompt remedial treatment to the patient's hypoglycemia condition. Even if the human body appears hypoglycemia for a short period of time may cause great danger, even pose a danger to life, so it is a good choice to use glucagon to solve this problem. Many clinical trials have shown that dihormone therapy (insulin infusion and glucagon) is the most promising way to control blood sugar, which can more accurately mimic the physiological way in which two hormones are secreted by human pancreatic islets. In view of the above problems, the control strategy and method of double hormone studied in this paper aims to further reduce the probability of hypoglycemia, so as to better reduce or even avoid the serious harm caused by hypoglycemia. In this paper, MPC and game theory are used to design the predictive controller for the two subsystems of double hormone control, and the cost function and switching rule are designed. At the same time, the switching control method is compared with the traditional single hormone control method and the double hormone control method, and the robustness test is carried out, which proves the superiority of the method. The ultimate purpose of the study is to design a reasonable and effective control method to coordinate the injection of two hormones and maximize the economic benefits by using model predictive control (MPC) and game theory. In this paper, based on MPC and game theory, we hope to get a new method and thought of diabetes treatment based on the "artificial pancreas" double hormone control scheme.
【学位授予单位】：北京化工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1

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