伴肺纤维化的MPO阳性ANCA相关性血管炎的临床研究
发布时间：2018-08-23 13:04
【摘要】：目的探讨伴随肺纤维化的髓过氧化物酶(MPO)阳性抗中性粒细胞胞浆抗体(ANCA)相关性血管炎患者临床特征及实验室指标间的相关性。方法将33例MPO阳性ANCA相关性血管炎患者分为伴肺纤维化改变的A组和不伴肺纤维化改变的B组,并以14例结缔组织病相关肺间质纤维化患者作为疾病对照组,12例健康体检者作为健康对照组。分析上述患者的临床资料及实验室指标。结果 B组患者血肌酐水平与疾病对照组及健康对照组相比均显著升高,A组患者血肌酐水平与疾病对照组及健康对照组相比具有一定程度升高,但差异无统计学意义;A组、B组以及疾病对照组患者血纤维蛋白原(FIB)、D二聚体(D-D)、超敏C反应蛋白(hsCRP)的水平均较健康对照组显著升高(均P0.05),且在A组中,MPO的表达水平与FIB值呈正相关(r=0.64,P0.05)。结论在肺纤维化疾病中,早期监测ANCA对于ANCA相关性血管炎的诊断具有一定临床价值,且ANCA靶抗原MPO水平在反映血栓形成风险中具有一定临床意义。
[Abstract]:Objective to investigate the clinical features of myeloperoxidase (MPO) positive anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis with pulmonary fibrosis. Methods Thirty-three patients with MPO positive ANCA associated vasculitis were divided into two groups: group A with pulmonary fibrosis and group B without pulmonary fibrosis. 14 cases of connective tissue disease associated pulmonary interstitial fibrosis were used as the disease control group and 12 healthy persons as the healthy control group. The clinical data and laboratory indexes of the above mentioned patients were analyzed. Results the serum creatinine level in group B was significantly higher than that in the disease control group and the healthy control group, and the serum creatinine level in group A was significantly higher than that in the disease control group and the healthy control group. However, there was no significant difference in serum fibrinogen (FIB) D dimer (D-D) and hypersensitive C-reactive protein (hsCRP) levels in group A and control group (P 0.05), and there was a positive correlation between the expression of (FIB) and FIB in group A (r 0.64 P 0.05). Conclusion in pulmonary fibrosis disease, early monitoring of ANCA has certain clinical value in the diagnosis of ANCA associated vasculitis, and the level of ANCA target antigen MPO has a certain clinical significance in reflecting the risk of thrombosis.
【作者单位】： 华中科技大学同济医学院附属同济医院检验科;武汉市第一医院临床免疫学实验室;华中科技大学同济医学院附属同济医院呼吸内科;
【基金】：武汉市卫生计生委科研基金资助项目(No.WX16D32)
【分类号】：R446.1;R593.2
，
本文编号：2199162
[Abstract]:Objective to investigate the clinical features of myeloperoxidase (MPO) positive anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis with pulmonary fibrosis. Methods Thirty-three patients with MPO positive ANCA associated vasculitis were divided into two groups: group A with pulmonary fibrosis and group B without pulmonary fibrosis. 14 cases of connective tissue disease associated pulmonary interstitial fibrosis were used as the disease control group and 12 healthy persons as the healthy control group. The clinical data and laboratory indexes of the above mentioned patients were analyzed. Results the serum creatinine level in group B was significantly higher than that in the disease control group and the healthy control group, and the serum creatinine level in group A was significantly higher than that in the disease control group and the healthy control group. However, there was no significant difference in serum fibrinogen (FIB) D dimer (D-D) and hypersensitive C-reactive protein (hsCRP) levels in group A and control group (P 0.05), and there was a positive correlation between the expression of (FIB) and FIB in group A (r 0.64 P 0.05). Conclusion in pulmonary fibrosis disease, early monitoring of ANCA has certain clinical value in the diagnosis of ANCA associated vasculitis, and the level of ANCA target antigen MPO has a certain clinical significance in reflecting the risk of thrombosis.
【作者单位】： 华中科技大学同济医学院附属同济医院检验科;武汉市第一医院临床免疫学实验室;华中科技大学同济医学院附属同济医院呼吸内科;
【基金】：武汉市卫生计生委科研基金资助项目(No.WX16D32)
【分类号】：R446.1;R593.2
，
本文编号：2199162
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