30例超重肥胖志愿者的间歇性断食干预研究

发布时间：2018-08-26 07:26

【摘要】：目的:本研究通过对30名超重肥胖志愿者进行为期8周的间歇性断食干预,以明确其带来的健康效应,及进一步探讨对运动步数、饮食行为、饥饿感、饱腹感和满足感的改变及安全性分析,为后期间歇性断食结合步行运动作为社区防治超重肥胖技术进行推广提供科学依据。方法:本研究以通过南昌市疾控微信平台招募的30名超重肥胖志愿者为研究对象。进行为期8周的间歇性断食干预,比较和分析干预前后的超重肥胖患者形态指标(身高、体重、臀围、腰围、体脂率及派生的腰臀比和体重指数)、安静血压、心率、血液(尿液)生化指标、饮食行为、VAS量表(饥饿感、饱腹感、满足感)、运动步数等指标,并对干预效果进行评价。结果:(1)通过8周干预,30名志愿者的身体形态指标均显著下降(P0.01)。其中,体重下降3.36±1.93kg、腰围减少5.11±4.79cm、臀围减少2.70±3.81cm、腰臀比下降0.03±0.04、体脂率降低1.71±1.63%、BMI下降1.20±0.75kg/m2。血脂血压方面,干预后DBP、SBP、GLU、TG、HDL-C、LDL-C均有所改善。其中,SBP,TG变化在干预前后有统计学意义(P0.05)。在肝肾功能方面,ALT、AST、ALB、UREA、CRE值在干预8周后均有下降,具有统计学意义(P0.05)。(2)8周每日平均运动步数为10987±1998,非断食日的平均运动步数为11070±1975,断食日的平均运动步数为10859±2210,间歇性断食日和非断食日的运动量差别没有统计学意义(F=0.141,P=0.708)。且非断食日运动步数(P=0.209)、断食日的运动步数(P=0.303)、每周平均运动步数(P=0.164)和非断食日与断食日的运动步数差异在8周之内均未显示有统计学意义(P0.05)。(3)干预8周后,受试者出现饥饿感下降和饱腹感上升(P0.05),而满足感未显示有统计学意义(P0.05)。(4)比较第1周、第4周、第8周CR、UE、EE得分,差异具有统计学意义。认知限制性进食(CR)维度得分增加了(F=4.23,P0.05),非控制进食维度(UE)得分(F=11.331,P0.05)和情绪性进食(EE)维度得分减少了(F=5.961,P0.05)。(5)8周内18名受试者出现不良反应,12名受试者未见不良反应。主要的不良反应为头晕(n=9,30.00%)和口渴(n=6,20.00%),其他的不良反应如胃胀气(n=2,6.67%),注意力下降(n=2,6.67%),低血糖(n=2,6.67%),腰背痛(n=2,6.67%),恶寒(n=1,3.33%)出现较少。结论:8周间歇性断食结合累计10000步步行运动可有效改善超重和肥胖志愿者的形态指标、血液生化指标、血压、肝肾功能相关指标,减肥效果良好。每天运动步数在7000-10000范围之内,特别是在非断食日内,受试者是可以耐受的,证明步行运动是间歇性断食一种很好的附加治疗方法。间歇性断食对饮食行为(CR,UR,EE)均产生了积极的变化,而且有利于降低饥饿感并增加饱腹感,这种变化有利于长期稳定地减少体重。总之,间歇性断食是一种效果好、简单易行、容易长期坚持的方法,这提示后期间歇性断食结合步行运动作为社区超重肥胖防治技术进行推广是可行的。
[Abstract]:AIM: To investigate the health effects of intermittent dietary intervention on 30 overweight and obese volunteers for 8 weeks, and to explore the changes and safety of exercise steps, dietary behavior, hunger, satiety and satisfaction in order to prevent and treat overweight in the community. Methods: Thirty overweight and obese volunteers recruited by the Nanchang CDC Weixin Platform were selected as the subjects of this study. Intermittent diet intervention was conducted for 8 weeks. Morphological indexes (height, weight, hip circumference, waist circumference, body fat rate and derivative) of overweight and obese patients before and after intervention were compared and analyzed. Waist-hip ratio and body mass index (BMI), quiet blood pressure, heart rate, blood (urine) biochemical indicators, dietary behavior, VAS (hunger, satiety, satisfaction), and the number of exercise steps were evaluated. Results: (1) After 8 weeks of intervention, 30 volunteers'body shape indicators were significantly decreased (P 0.01). Among them, body weight loss was 3.36 (1.93 kg), and so on. The waist circumference decreased by 5.11+4.79 cm, the hip circumference decreased by 2.70+3.81 cm, the waist-hip ratio decreased by 0.03+0.04, the body fat rate decreased by 1.71+1.63%, and the BMI decreased by 1.20+0.75 kg/m2. The blood lipid and blood pressure of DBP, SBP, GLU, TG, HDL-C and LDL-C were improved after the intervention. The changes of SBP and TG were statistically significant before and after the intervention (P 0.05). E value decreased after 8 weeks of intervention, with statistical significance (P 0.05). (2) The average daily exercise pace of 8 weeks was 10987 There was no significant difference between the exercise steps on the breaking day (P = 0.209), the exercise steps on the breaking day (P = 0.303), the average exercise steps per week (P = 0.164) and the exercise steps on the breaking day and the breaking day (P 0.05). (3) After 8 weeks of intervention, the subjects showed a decrease in hunger and an increase in satiety (P 0.05). Comparing the scores of CR, UE and EE in the first week, the fourth week and the eighth week, the difference was statistically significant. The scores of CR, UE and EE increased (F = 4.23, P 0.05), UE and EE decreased (F = 11.331, P 0.05) and EE decreased (F = 5.961, P 0.05) in the fifth week. The main adverse reactions were dizziness (n = 9,30.00%) and thirst (n = 6,20.00%). Other adverse reactions were gastric distention (n = 2,6.67%), decreased attention (n = 2,6.67%), hypoglycemia (n = 2,6.67%), low back pain (n = 2,6.67%) and cold (n = 1,3.33%). Exercise can effectively improve the morphological indexes, blood biochemical indexes, blood pressure, liver and kidney function related indexes of overweight and obese volunteers, and the weight loss effect is good. Methods. Intermittent fasting has a positive effect on dietary behavior (CR, UR, EE) and is conducive to reducing hunger and increasing satiety. This change is conducive to long-term stable weight loss. Exercise as a community overweight and obesity prevention and control technology is feasible.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R589.2

【参考文献】