ANCA相关性血管炎伴血清补体C3降低的临床分析

发布时间：2018-08-26 13:03

【摘要】：目的探讨血清补体C3(serum complement C3,sC3)降低的抗中性粒细胞胞浆抗体相关性血管炎(AAV)患者的临床病理特征及预后。方法回顾性分析2011年1月至2016年3月我院肾内科穿刺活检确诊的54例AAV患者的临床及病理资料。采用免疫比浊法检测sC3,以我院sC3测值的正常范围下线值为截点将AAV患者分成低sC3组(sC30.9 g/L)与正常sC3组(sC3≥0.9 g/L),比较2组患者流行病学、实验室检查、肾脏病理、临床症状、治疗及预后的差异。结果低sC3组,血肌酐基线值明显高于正常sC3组(P=0.008);C反应蛋白、eGFR值明显低于正常sC3组(P值分别0.001、0.012);快速肾功能衰竭以及即时透析的发生率明显高于正常sC3组(P值分别为0.035、0.014);缓解率显著低于正常sC3组(P0.001)。Kaplan-Meier生存分析显示低sC3组的肾脏累积生存率明显低于正常sC3组(log-rank=10.197,P=0.001)。结论血清补体C3降低的AAV患者病情严重,进展较快,预后差。
[Abstract]:Objective to investigate the clinicopathological features and prognosis of patients with (AAV) with decreased serum complement C3 (serum complement C 3s C 3 (anti neutrophil cytoplasmic antibody). Methods the clinical and pathological data of 54 AAV patients diagnosed by puncture biopsy from January 2011 to March 2016 were retrospectively analyzed. The patients with AAV were divided into low sC3 group (sC30.9 g / L) and normal sC3 group (sC3 鈮，

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