雌激素调节骨代谢作用的研究进展

发布时间：2018-08-26 15:58

【摘要】：雌激素作为一种重要的内源性甾体类激素,具有广泛的生物活性,其可以通过与雌激素受体结合,对生殖系统,中枢神经系统,心血管系统,免疫系统,胰岛功能以及骨代谢等多个方面产生影响。雌激素缺乏是导致绝经后骨质疏松症的主要原因,这一结论已经被多方科研人员证实并得到公认,故雌激素也成为治疗绝经后骨质疏松的主要手段。本文总结了雌激素的来源、雌激素受体的分类和分布、雌激素与骨质疏松的关系、雌激素影响骨代谢的作用机制以及雌激素治疗绝经后骨质疏松症在临床上的应用。其中分别从雌激素通过直接作用和间接作用两方面抑制破骨细胞的重吸收;从减少细胞凋亡、降低氧化应激反应以及减弱NF-k B的活性三种机制总结雌激素增加成骨细胞的形成;从雌激素通过干预骨重建和重吸收过程进而影响骨细胞的整体代谢过程三个大方面入手,将近年来雌激素对骨代谢的作用及机制进行整理归纳,以期为绝经后骨质疏松症的基础实验研究及临床治疗提供更为系统的理论依据。
[Abstract]:Estrogen, as an important endogenous steroid hormone, has a wide range of biological activities, it can be combined with estrogen receptor, the reproductive system, the central nervous system, the cardiovascular system, the immune system, Islet function and bone metabolism are affected. Estrogen deficiency is the main cause of postmenopausal osteoporosis. This conclusion has been confirmed and recognized by many researchers, so estrogen has become the main treatment of postmenopausal osteoporosis. The origin of estrogen, the classification and distribution of estrogen receptor, the relationship between estrogen and osteoporosis, the mechanism of estrogen affecting bone metabolism and the clinical application of estrogen in the treatment of postmenopausal osteoporosis were summarized. Estrogen inhibits the reabsorption of osteoclasts through direct and indirect effects, and concludes that estrogen increases the formation of osteoblasts by reducing cell apoptosis, reducing oxidative stress and decreasing the activity of NF-k B. The effects and mechanisms of estrogen on bone metabolism in recent years were summarized from three aspects: estrogen interfered with the process of bone reconstruction and reabsorption and then affected the whole metabolism of bone cells. In order to provide a more systematic theoretical basis for the basic experimental study and clinical treatment of postmenopausal osteoporosis.
【作者单位】：黑龙江中医药大学;黑龙江中医药大学中医药研究院;
【基金】：黑龙江省自然科学基金面上项目(H2016072) 黑龙江省博士后资助项目(LBH-Z13200) 黑龙江省留学归国人员科学基金资助项目(LC08C26)
【分类号】：R580

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