甲硫酸新斯的明对百草枯中毒的疗效观察
发布时间：2018-09-04 07:40
【摘要】：目的探讨甲硫酸新斯的明对百草枯中毒的治疗作用。方法回顾性分析2014年7月至2016年6月在我院治疗的百草枯中毒患者43例,根据患者是否加用新斯的明治疗分为常规治疗组(n=21)及新斯的明组(n=22)。对比两组患者入院时,入院后48 h的血清TNF-α、IL-6、IL-10水平及急性生理学及慢性健康状况(APACHEⅡ)评分、肺损伤评分(lung injury score,LIS);对比两组患者3个月内病死率。结果两组患者入院当天血清TNF-α、IL-6、IL-10水平相近,差异无统计学意义(P0.05);治疗2 d后,新斯的明组血清TNF-α、IL-6水平明显低于常规治疗组(P0.01)。两组患者入院当天APACHEⅡ评分、LIS评分相近,差异无统计学意义(P0.05);分别治疗2 d后,新斯的明组APACHEⅡ评分、LIS评分低于常规治疗组(P0.05)。两组患者在3 d内病死率差异无统计学意义(P0.05),但新斯的明组7 d及30 d病死率低于常规治疗组(P0.05)。结论百草枯患者早期加用新斯的明治疗,可减少TNF-α、IL-6炎性介质的合成,从而维持各个器官正常功能,减轻肺损伤,提高生存率。
[Abstract]:Objective to investigate the therapeutic effect of neostigmine methyl sulfate on paraquat poisoning. Methods 43 cases of paraquat poisoning treated in our hospital from July 2014 to June 2016 were retrospectively analyzed. According to whether the patients were treated with neostigmine or not, they were divided into two groups: routine treatment group (n = 21) and neostigmine group (n = 22). The levels of serum TNF- 伪 IL-6 IL-10, acute physiology and chronic health status (APACHE 鈪，
本文编号：2221429
[Abstract]:Objective to investigate the therapeutic effect of neostigmine methyl sulfate on paraquat poisoning. Methods 43 cases of paraquat poisoning treated in our hospital from July 2014 to June 2016 were retrospectively analyzed. According to whether the patients were treated with neostigmine or not, they were divided into two groups: routine treatment group (n = 21) and neostigmine group (n = 22). The levels of serum TNF- 伪 IL-6 IL-10, acute physiology and chronic health status (APACHE 鈪，
本文编号：2221429
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