系统性红斑狼疮患者发生肺动脉高压危险因素的Meta分析

发布时间：2018-09-05 08:51

【摘要】：目的探讨系统性红斑狼疮(SLE)患者发生肺动脉高压(PAH)的危险因素。方法通过计算机检索和文献追溯的方法,检索Pub Med、中国知网和万方数据知识服务平台中SLE患者发生PAH危险因素的相关文献,时间限定为建库至2015年1月。两名研究员独立进行文献筛选并提取文献资料,包括第一作者、发表时间、病例收集时间、样本量、研究因素,采用纽卡斯尔-渥太华量表(NOS)对纳入文献进行质量评价。依据比值比(OR值)及其95%CI评估各临床表现及实验室指标与SLE患者发生PAH的关系。结果纳入15篇病例对照研究,NOS评分均≥7分,文献总体质量较高。出现雷诺现象的SLE患者发生PAH的风险高于未出现雷诺现象者〔OR=3.96,95%CI(2.94,5.34),P0.05〕。有无皮肤血管炎的SLE患者发生PAH的风险比较,差异无统计学意义(P0.05)。抗核糖核蛋白(RNP)抗体阳性的SLE患者发生PAH的风险高于抗RNP抗体阴性者〔OR=3.32,95%CI(2.37,4.66),P0.05〕。抗心磷脂(ACL)-IgG抗体阳性的SLE患者发生PAH的风险高于抗ACL-IgG抗体阴性者〔OR=3.36,95%CI(2.37,4.76),P0.05〕。合并浆膜炎的SLE患者发生PAH的风险高于无浆膜炎者〔OR=2.63,95%CI(1.50,4.59),P0.05〕。合并肺间质病变的SLE患者发生PAH的风险高于无肺间质病变者〔OR=4.65,95%CI(3.13,6.88),P0.05〕。结论雷诺现象、抗RNP抗体阳性、抗ACL-IgG抗体阳性、浆膜炎、肺间质病变是SLE患者发生PAH的危险因素。
[Abstract]:Objective to investigate the risk factors of pulmonary hypertension (PAH) in patients with systemic lupus erythematosus (SLE). Methods by means of computer retrieval and literature tracing, we searched the literature about the risk factors of PAH in SLE patients in Pub Med, China knowledge Network and Wanfang data knowledge Service platform. The time limit was to build the database until January 2015. The two researchers independently screened and extracted the literature, including the first author, publication time, case collection time, sample size and factors. The quality of the literature was evaluated by Newcastle Ottawa scale (NOS). According to the ratio (OR) and its 95%CI, the relationship between the clinical manifestations and laboratory indexes and the incidence of PAH in SLE patients was evaluated. Results the NOS scores of 15 case-control studies were all 鈮，

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