二甲双胍干预皮肤黏膜型白塞病的前瞻性临床研究
发布时间：2018-09-07 15:08
【摘要】：目的:探索二甲双胍对白塞病的临床治疗价值.方法:记录15例活动期白塞病患者经二甲双胍治疗入院时、出院时临床症状、血常规、C-反应蛋白、血沉、肝肾功能、血糖水平,作历史对照;并随访3月,记录疾病控制情况及副作用发生情况.结果:患者出院时临床症状均得到控制,口腔溃疡评分较入院时明显下降(P=0.000 0),每月复发次数,较入院前明显下降(P=0.000 1).患者治疗炎症指标包括白细胞计数、C-反应蛋白、血沉和Ig A明显下降(P0.05).患者出院时,未发现二甲双胍对红细胞计数、血红蛋白明显影响,未发现对肝肾功能及血糖影响.同时发现患者谷氨酸-丙酮酸转氨酶治疗后下降,肾小球滤过率升高(P0.05).6例(40%)患者出现腹泻,4例(27%)患者出现恶心、呕吐、食欲下降,2例(13.3%)患者出现乏力,尚可耐受.结论:二甲双胍可降低白塞病皮肤黏膜病变复发率,降低活动期血沉、C-反应蛋白,可能是白塞病治疗可供选择的药物之一.
[Abstract]:Objective: To explore the clinical value of metformin in the treatment of Behcet's disease. Methods: The clinical symptoms, blood routine, C-reactive protein, erythrocyte sedimentation rate, liver and kidney function, blood glucose levels of 15 patients with active Behcet's disease were recorded at the time of admission after metformin treatment. The clinical symptoms were controlled at discharge, and the oral ulcer score was significantly lower than that at admission (P = 0.000 0). The number of recurrences per month was significantly lower than that before admission (P = 0.000 1). Inflammatory indicators included leukocyte count, C-reactive protein, erythrocyte sedimentation rate and Ig A decreased significantly (P 0.05). At the same time, 6 patients (40%) had diarrhea, 4 patients (27%) had nausea, vomiting, loss of appetite, and 2 patients (13.3%) had fatigue, which was tolerable. Guanidine can reduce the recurrence rate of skin and mucosal lesions of Behcet's disease, reduce active ESR and C-reactive protein, which may be one of the alternative drugs for the treatment of Behcet's disease.
【作者单位】： 复旦大学附属华东医院免疫风湿科;
【基金】：上海卫生系统第二批重要疾病联合攻关重点项目(2014ZYJB0010)
【分类号】：R597.9
[Abstract]:Objective: To explore the clinical value of metformin in the treatment of Behcet's disease. Methods: The clinical symptoms, blood routine, C-reactive protein, erythrocyte sedimentation rate, liver and kidney function, blood glucose levels of 15 patients with active Behcet's disease were recorded at the time of admission after metformin treatment. The clinical symptoms were controlled at discharge, and the oral ulcer score was significantly lower than that at admission (P = 0.000 0). The number of recurrences per month was significantly lower than that before admission (P = 0.000 1). Inflammatory indicators included leukocyte count, C-reactive protein, erythrocyte sedimentation rate and Ig A decreased significantly (P 0.05). At the same time, 6 patients (40%) had diarrhea, 4 patients (27%) had nausea, vomiting, loss of appetite, and 2 patients (13.3%) had fatigue, which was tolerable. Guanidine can reduce the recurrence rate of skin and mucosal lesions of Behcet's disease, reduce active ESR and C-reactive protein, which may be one of the alternative drugs for the treatment of Behcet's disease.
【作者单位】： 复旦大学附属华东医院免疫风湿科;
【基金】：上海卫生系统第二批重要疾病联合攻关重点项目(2014ZYJB0010)
【分类号】：R597.9
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