三甲复脉汤化裁方治疗甲亢的疗效观察及对TNF-α的影响

发布时间：2018-09-09 11:32

【摘要】：目的：通过观察三甲复脉汤化裁方治疗肝肾阴虚型甲亢患者中医证候以及FT3、FT4、TSH、TNF-α各项指标变化情况,从而探讨三甲复脉汤化裁方治疗甲亢的作用机制以及对TNF-α的影响。方法：选取病例皆来自于2014年03月至2014年12月黑龙江中医药大学附属第一医院门诊并经诊断确定为甲亢(肝肾阴虚型)的患者64例,并将其随机分为治疗组与对照组,两组病例数均为32例。治疗组应用三甲复脉汤化裁和甲巯咪哗进行治疗。对照组应用甲巯咪哗治疗。本试验以4周为一个疗程,定期检测安全性指标和疗效性观察指标结果(1)两组中医证候疗效比较P0.05,差异有统计学意义,其中治疗组总有效率为97%,而对照组则为83%,治疗组优于对照组。单个症状积分比较,治疗组在头晕眼花、颈前肿大症状改善情况均优于对照组(P0.05)。(2)两组西医疗效比较P0.05,差异有统计学意义,其中治疗组总有效率为96%,而对照组则为76%,治疗组明显优于对照组(3)两组治疗前FT3、FT4、TSH比较,P0.05,差异无统计学意义,具有可比性；两组治疗后,二者FT3、FT4、TSH的组内比较,P0.05,说明两组甲状腺功能均有改善,两组治疗后FT3、FT4、TSH组间比较,P0.05,差异无统计学意义。(4)治疗组治疗前后和对照组治疗前后TNF-α比较P0.05,差异有统计学意义。两组治疗后TNF-α比较P0.05,差异有统计学意义,且治疗组优于对照组。结论(1)三甲复脉汤化裁方在改善中医证候方面疗效明显,尤其是在改善头晕眼花、颈前肿大方面疗效更为突出。(2)三甲复脉汤化裁方可以降低FT3、FT4、升高TSH。(3)三甲复脉汤化裁方有效的降低了TNF-α水平。
[Abstract]:Objective: to observe the changes of TCM syndromes and FT3,FT4,TSH,TNF- 伪 indexes in the treatment of hyperthyroidism of liver and kidney yin deficiency type by Sanjiafumai decoction, so as to explore the mechanism of Sanjiafumai decoction in treating hyperthyroidism and its effect on TNF- 伪. Methods: from March 2014 to December 2014, 64 patients with hyperthyroidism (liver and kidney yin deficiency) were selected from outpatient clinic of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine, and were randomly divided into treatment group and control group. There were 32 cases in both groups. The treatment group was treated with Sanjia Fumai decoction and cimercaptopril. The control group was treated with cimetidine. The results of this study were as follows: (1) the curative effect of TCM syndrome in the two groups was compared with that of P0.05, and the difference was statistically significant. The total effective rate in the treatment group was 97 and 833 in the control group, which was superior to that in the control group. Single symptom score comparison, the treatment group in dizziness, cervical swelling symptoms were better than the control group (P0.05). (2) two groups of Western medicine efficacy comparison P0.05, the difference was statistically significant, The total effective rate of the treatment group was 96g and that of the control group was 76.The treatment group was obviously superior to the control group (3) the FT3,FT4,TSH of the two groups was significantly higher than that of the control group (P 0.05), the difference was not statistically significant and comparable. The results showed that the thyroid function of the two groups was improved, and there was no significant difference between the two groups after FT3,FT4,TSH treatment. (4) the TNF- 伪 in the treatment group was significantly higher than that in the control group before and after treatment (P 0.05). There was significant difference in TNF- 伪 between the two groups after treatment (P 0.05), and the treatment group was superior to the control group. Conclusion (1) Sanjia Fumai decoction is effective in improving TCM syndromes, especially in improving dizziness. (2) Sanjia Fumai decoction can reduce FT3,FT4, and increase TSH. (3) Sanjia Fumai decoction can effectively reduce the level of TNF- 伪.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R581.1

【参考文献】