规律簇集间断的短回文重复序列及其相关核酸酶9系统应用于糖尿病领域的研究进展
发布时间：2018-09-10 09:08
【摘要】：规律簇集间断的短回文重复序列及其相关核酸酶9(CRISPR/Cas9)系统是一种新型的基因编辑工具,可同时研究多个基因的功能及相互关系,已在多种疾病中显示出巨大的潜在价值。与其他基因编辑技术,如锌指核酸酶(ZFNs)和转录激活样核酸酶(TALENs)相比,CRISPR/Cas9更简单、高效。随着CRISPR/Cas9系统技术的广泛应用,在糖尿病领域有不少相关研究出现。本文从基础到临床对CRISPR/Cas9在糖尿病领域的研究进展作文献回顾,期待为相关人员提供参考。
[Abstract]:The regularly clustered short palindrome repeat sequence and its associated nuclease 9 (CRISPR/Cas9) system is a novel gene editing tool, which can simultaneously study the functions and relationships of multiple genes, and has shown great potential value in many diseases. Compared with other gene editing techniques, such as zinc finger nuclease (ZFNs) and transcription-activated nuclease (TALENs), CRISPR-Cas9 is simpler and more efficient. With the wide application of CRISPR/Cas9 system technology, there are many related studies in the field of diabetes mellitus. This article reviews the research progress of CRISPR/Cas9 in diabetes mellitus from basic to clinical, and looks forward to providing reference for related personnel.
【作者单位】： 四川大学华西医院老年医学中心;四川大学华西医院血液病科;
【基金】：四川省科技厅重点研发项目(2017SZ0146)
【分类号】：R587.1
本文编号：2234004
[Abstract]:The regularly clustered short palindrome repeat sequence and its associated nuclease 9 (CRISPR/Cas9) system is a novel gene editing tool, which can simultaneously study the functions and relationships of multiple genes, and has shown great potential value in many diseases. Compared with other gene editing techniques, such as zinc finger nuclease (ZFNs) and transcription-activated nuclease (TALENs), CRISPR-Cas9 is simpler and more efficient. With the wide application of CRISPR/Cas9 system technology, there are many related studies in the field of diabetes mellitus. This article reviews the research progress of CRISPR/Cas9 in diabetes mellitus from basic to clinical, and looks forward to providing reference for related personnel.
【作者单位】： 四川大学华西医院老年医学中心;四川大学华西医院血液病科;
【基金】：四川省科技厅重点研发项目(2017SZ0146)
【分类号】：R587.1
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