经皮氧分压在2型糖尿病周围神经病变中的变化及其临床意义

发布时间：2018-09-10 12:07

【摘要】：目的探讨经皮氧分压(TcPO_2)在T2DM合并周围神经病变(DPN)患者的变化及临床意义。方法选取2014年10月至2015年9月于江苏省连云港市第一人民医院内分泌科住院的T2DM患者222例,采用TCM400经皮氧分压检测仪检测50名健康对照(NC)组和222例T2DM患者仰卧位足背TcPO_2值,依据神经传导速度(NCV)将T2DM患者分为DPN组102例和非DNP(NDPN)组120例,分析各组一般临床资料。结果与NC组和NDPN组比较,DPN组仰卧位TcPO_2值降低,与病程、多伦多神经病变评分(TCSS)、HbA_1c、SUA、FPG、NCV呈正相关。与正常TcPO_2组比较,低TcPO_2组DPN患者增加,运动和感觉神经NCV降低。Logistic回归分析显示,TcPO_2是DPN的独立危险因素。结论 DPN患者仰卧位TcPO_2降低,是DPN发生发展的危险因素,可能有助于DPN的早期诊断。
[Abstract]:Objective to investigate the changes and clinical significance of percutaneous partial pressure of oxygen (TcPO_2) in T2DM patients with peripheral neuropathy (DPN). Methods from October 2014 to September 2015, 222 T2DM patients in the Department of Endocrinology, Lianyungang City, Jiangsu Province, were selected. The TcPO_2 values of supine foot in 50 healthy control (NC) patients and 222 T2DM patients were detected by TCM400 percutaneous oxygen partial pressure detector. According to nerve conduction velocity (NCV), patients with T2DM were divided into two groups: DPN group (n = 102) and non-DNP (NDPN) group (n = 120). Results compared with the NC group and the NDPN group, the supine position TcPO_2 value in the DPN group decreased, and was positively correlated with the course of the disease and the Toronto neuropathy score (TCSS) / HbA1cSUAGV nCV. Compared with the normal TcPO_2 group, the DPN patients in the low TcPO_2 group increased and the motor and sensory nerve NCV decreased. Logistic regression analysis showed that TcPO2 was an independent risk factor for DPN. Conclusion the decrease of TcPO_2 in supine position in patients with DPN may be a risk factor for the development of DPN and may be helpful to the early diagnosis of DPN.
【作者单位】：徐州医科大学附属连云港医院内分泌科;南京医科大学第一附属医院内分泌科;
【分类号】：R587.2

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