血清促甲状腺激素与血脂谱在新诊断2型糖尿病患者中的相关性研究

发布时间：2018-09-10 14:28

【摘要】：目的:在新诊断2型糖尿病甲状腺功能正常的患者中探讨血清促甲状腺激素与血脂谱的相关性。方法:选取436例首次诊断为2型糖尿病,且甲状腺功能正常的患者,按TSH水平{(2.2IU/m L),(促甲状腺激素,Thyroid Stimulating Hormone,以下简称TSH)}分为A组和B组(TSH水平较低的组为A组,TSH水平较高组为B组),分别比较总体、男性、女性患者中两组之间的年龄、BMI(体重指数,Body mass index,以下简称BMI)、血压、糖脂代谢等指标的差异,血清TSH与血脂之间是否存在相关关系应用相关性分析进行研究。结果:(1)在所有受试者中,BMI在B组中明显高于A组,组间存在显著差异(P=0.01)。(2)在女性受试者中,TC(总胆固醇,Total cholesterol,以下简称TC)在A组中高于B组,差异具有统计学意义(P=0.03),且在Pearson相关分析中TC、Log HDL-C(Log High-density lipoprotein cholesterol,经Log转换的高密度脂蛋白,以下简称Log HDL-C)与TSH水平明显相关,但在校正年龄、吸烟、BMI、DBP(Diastolic blood pressure,舒张压,以下简称DBP)、FPG(空腹血糖)、HBA1C(糖化血红蛋白)、FT3(游离三碘甲状腺原氨酸)及FT4(游离甲状腺素)的影响后,TSH与TC、Log HDL-C间均未再发现存在相关。(3)在男性受试者中,偏相关分析结果显示TC与血清TSH间呈显著正相关(P=0.023),且在多元线性回归分析中,TSH与TC也存在显著正相关(β=0.05,P=0.032),即使相关指标在不同TSH水平组间并未发现存在统计学差异。(4)高脂血症{包括高TC血症、高LDL-C(Low-density lipoprotein cholesterol低密度脂蛋白胆固醇,以下简称LDL-C)血症、高TG血症(甘油三酯,Triglyceride,以下简称TG)}的患病率,在不同血清TSH水平间未发现存在显著差异。结论:在甲状腺功能正常的首次诊断为2型糖尿病的男性患者中,血清TSH水平对血脂代谢存在显著影响,且这一影响独立于甲状腺激素的作用。
[Abstract]:Objective: to investigate the correlation between serum thyroid stimulating hormone (TSH) and blood lipids in newly diagnosed type 2 diabetic patients with normal thyroid function. Methods: 436 patients with type 2 diabetes mellitus and normal thyroid function were selected. According to 2.2IU/m L), (thyrotropin Stimulating Hormone, (TSH)}, they were divided into two groups: group A and group B (group A with lower TSH level and group B with higher TSH level). The difference of body mass index (BMI) and body mass index, (BMI), blood pressure, glucose and lipid metabolism) between the two groups, and the correlation between serum TSH and blood lipids were analyzed. Results: (1) in all subjects, the BMI of group B was significantly higher than that of group A, and there was a significant difference between the two groups (P0. 01). (2). TC (Total cholesterol, of total cholesterol) was higher in group A than that in group B in female subjects. The difference was statistically significant (P0. 03). In Pearson correlation analysis, TC,Log HDL-C (Log converted high density lipoprotein (Log HDL-C) was significantly correlated with TSH level, but at adjusted age, smoking was associated with DBP (Diastolic blood pressure, diastolic blood pressure. (3) there was no correlation between DBP and TC,Log HDL-C after the effects of FT3 (free triiodothyronine) and FT4 (free triiodothyronine) on HBA1C (glycosylated hemoglobin). The results of partial correlation analysis showed that there was a significant positive correlation between TC and serum TSH (P0. 023), and in multivariate linear regression analysis, there was also a significant positive correlation between TSH and TC (尾 0. 05% P0. 032), even though there was no statistical difference between the related indexes in different TSH level groups. (4) hyperlipidemia {including hyperlipidemia, There was no significant difference in the prevalence of high LDL-C (Low-density lipoprotein cholesterol low density lipoprotein cholesterol (LDL-C) and high TG (TG) among different serum TSH levels. Conclusion: in the male patients with type 2 diabetes mellitus with normal thyroid function, serum TSH level has a significant effect on the metabolism of blood lipids, and this effect is independent of the effect of thyroid hormone.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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