甲亢患者血清尿酸水平与发生房颤的相关性分析

发布时间：2018-10-04 20:31

【摘要】：目的分析血清尿酸水平与甲状腺功能亢进症患者心房颤动的关系。方法回顾性收集2013年10月-2015年10月于该院就诊的227例甲亢患者临床资料,根据是否合并房颤,分为甲亢伴房颤组(n=49)和甲亢无房颤组(n=178),排外除甲亢以外其他疾病导致的房颤及其他可以引起尿酸水平变化的因素。记录入选患者的一般资料、实验室检查及心脏彩超结果,并对这些数据与房颤发生之间的关系进行单因素和多因素Logistic回归分析。结果甲亢伴房颤组的年龄、甲亢病程、尿素氮、肌酐、尿酸、球蛋白、左心房前后径及左心室舒张末期内径均高于甲亢无房颤组(P0.05),甲亢伴房颤组的肾小球滤过率、总胆固醇、高密度脂蛋白、低密度脂蛋白、白蛋白及左室射血分数低于甲亢无房颤组(P0.05)。通过多因素Logistic回归分析显示年龄(^OR:1.097,95%CI:1.036,1.160)、尿酸(^OR:1.009,95%CI:1.002,1.016)、左心房前后径(^OR:1.294,95%CI:1.134,1.476)及左室射血分数(^OR:0.902,95%CI:0.814,1.000)是甲亢患者房颤发生的独立相关因素。结论尿酸水平是甲亢患者房颤发生的危险因素,年龄、左心房前后径和左室射血分数也与甲亢患者房颤发生存在独立相关性。
[Abstract]:Objective to analyze the relationship between serum uric acid level and atrial fibrillation in patients with hyperthyroidism. Methods the clinical data of 227 patients with hyperthyroidism from October 2013 to October 2015 were collected retrospectively. The patients were divided into hyperthyroidism with atrial fibrillation group (nnn49) and hyperthyroidism without atrial fibrillation group (nf178). Atrial fibrillation caused by diseases other than hyperthyroidism and other factors that could cause changes in uric acid level were excluded. The results of general data, laboratory examination and echocardiography were recorded, and the relationship between these data and atrial fibrillation was analyzed by univariate and multivariate Logistic regression analysis. Results the age, course of hyperthyroidism, urea nitrogen, creatinine, uric acid, globulin, left atrial anteroposterior diameter and left ventricular end-diastolic diameter in hyperthyroidism with atrial fibrillation group were higher than those in hyperthyroidism without atrial fibrillation group (P0.05). The glomerular filtration rate and total cholesterol in hyperthyroidism with atrial fibrillation group were higher than those in hyperthyroidism without atrial fibrillation group. High density lipoprotein, low density lipoprotein, albumin and left ventricular ejection fraction were lower than hyperthyroidism without atrial fibrillation group (P0.05). Multivariate Logistic regression analysis showed that age (^ OR:1.097,95%CI:1.036,1.160), uric acid (OR:1.009,95%CI:1.002,1.016), left atrial anteroposterior diameter (OR:1.294,95%CI:1.134,1.476) and left ventricular ejection fraction (OR:0.902,95%CI:0.814,1.000) were independent correlation factors of atrial fibrillation in hyperthyroidism patients. Conclusion uric acid level is a risk factor for atrial fibrillation in patients with hyperthyroidism. Age, anterior and posterior diameter of left atrium and ejection fraction of left ventricle are also associated with atrial fibrillation in patients with hyperthyroidism.
【作者单位】：南昌大学第二附属医院内分泌代谢科;
【分类号】：R541.75;R581.1

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